Ajinomoto Co., Ltd.

Akira Takahara

Yukitsugu Ono

Seiji Niwa

Tomoko Takeda

Hajime Koganei

Seiji Ohno

Morikazu Kito

Satoshi Iwayama

Shinichi Fujita

Kayo Otani

Takashi Yamamoto

Yuki Kajigaya

Masako Hagihara

Akiko Okajima

Tadakiyo Nakagawa

Kazuyuki Sagi

Kaoru Yoshida

Takashi Kayahara

Masataka Shoji

Shunji Takehana

Yumiko Fukuda

Keiko Moki

Tomoyuki Onishi

Hiroyuki Matsueda

Munetaka Tokumasu

Hisayuki Uneyama

Yoko Masuzawa

Chika Nakanishi

Akira Nakajo

The invention relates to a compound represented by the following general formula (1) or its analogue, which selectively inhibit N-type calcium channels or its analogue, and to a method for treating pain etc. comprising the compound represented by the following general formula (1) or its analogue to a patient in need of such treatment: wherein, A represents CH&#x2550;CH, etc., a, b, c and d represents CH etc., R1, R2, R3, R4, R5 and R6 represents H etc., V&#x2014;W represents C&#x2550;C, etc., n represents 0 to 3, Y1 represents O etc., B represents &#x2014;(CH2)vCHR21 wherein v is 0 to 3, R21 represents H, a lower alkyl group or the like, etc., G represents &#x2014;CO&#x2014;, a covalent bond, etc., m is 0 to 6, R7 and R8 represents H, a lower alkyl group, &#x2014;COR18a, &#x2014;COOR20 wherein R18a and R20 each represents a lower alkyl group or the like, etc.

Diarylalkene derivatives and novel diarylalkane derivatives

Achiral pyrimidine derivatives and pyridine derivatives of the following formulae or analogs thereof have selective N-type calcium channel antagonistic activity and showed analgesic action when they were taken orally. They are useful as therapeutic agents for pains and various diseases associated with the N-type calcium channels. 

Pyridine compounds useful as N-type calcium channel antagonists

Achiral pyrimidine derivatives and pyridine derivatives of the following formulae or analogs thereof have selective N-type calcium channel antagonistic activity and showed analgesic action when they were taken orally. They are useful as therapeutic agents for pains and various diseases associated with the N-type calcium channels 

Pyrimidine compounds useful as N-type calcium channel antagonists

Compounds having a selective N-type calcium channel antagonistic activity are provided. Dihydropyridine derivatives represented by the following formula: analogs thereof and pharmaceutically acceptable salts thereof have an activity of selectively inhibiting the action of N-type calcium channel, and they are used as therapeutic agents for various diseases relating to N-type calcium channel.

Dihydropyridine derivatives

Dihydropyrimidine derivatives of the following formula or analogs thereof have selective N-type calcium channel antagonistic activity, and they are used as therapeutic agents for various diseases participating in the N-type calcium channels.

Dihydropyrimidine compounds and compositions containing the same

Benzamidine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof are provided. These compounds have an effect of inhibiting activated blood-coagulation factor X, and they are useful as agents for preventing or treating various diseases caused by thrombi or emboli.

Benzamidine derivative

Benzamidine derivatives

Dihydropyridine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof have an activity of selectively inhibiting the action of N-type calcium channel. They are used as remedies for various diseases relating to the N-type calcium channel.

Dihydropyridine derivative

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Kawasaki, Japan

Akira Takahara