Showa Denko K.k.

Akira Shibuya

Hiroshi Ishii

Makoto Saito

Hideo Miyata

Motoki Murai

Takanori Aoki

Takamitsu Kobayashi

Yoshiaki Miyota

Hidemasa Aoki

Shinya Tsukamoto

Manabu Kuwajima

Hiroshi Uchida

Yasuyuki Ueda

Motoaki Kamachi

Norihito Nishimura

Shinichi Yorozuya

Kimitaka Ohshiro

Yoshio Fujiwara

Asuka Toda

Akio Kuroiwa

Masaru Yasuda

Atsushi Tsuchiya

Akio Okamura

Provided is a method for producing an orotic acid derivative, the method comprising a condensation step of performing, under a basic condition, a condensation reaction between an orotic acid halide represented by General Formula (I) and a compound represented by General Formula (II) to generate an orotic acid derivative represented by General Formula (III); and a neutralization crystallization step of precipitating crystals of orotic acid by neutralization crystallization to separate a liquid containing the orotic acid derivative from the crystals of orotic acid, after the condensation step. In General Formula (I), (II), or (III), X is a halogen atom, and A is a group represented by General Formula (A-1) or (A-2). In General Formula (A-1) or (A-2), Ris a hydrogen atom or an organic group, and Rand Rare each independently an organic group. In a case where Ris an organic group, Rand Rmay be bonded to each other to form a ring. 

Method for producing orotic acid derivative

A method of producing an N,N-disubstituted amide of the present invention is a method of reacting a nitrile with an alcohol in the presence of a catalyst, wherein the nitrile is a compound represented by RCN (Rrepresents an alkyl group having 10 or less carbon atoms or an aryl group having 10 or less carbon atoms), wherein the alcohol is a compound represented by ROH (Rrepresents an alkyl group having 10 or less carbon atoms), wherein the catalyst is a metal salt represented by MXn (M represents a metal cation having an oxidation number of n, X represents a monovalent anion including a substituted sulfonyl group represented by &#x2014;S(&#x2550;O)&#x2014;R(Rrepresents a hydrocarbon group having 10 or less carbon atoms or a group in which some or all of hydrogen atoms in the hydrocarbon group are substituted with fluorine atoms), and n represents an integer of 1 to 4), a substituent bonded to a carbon atom in a carbonyl group of the N,N-disubstituted amide is R, and two substituents bonded to nitrogen atoms in an amide group are both R.

Method of producing N,N-disubstituted amide and catalyst for producing N,N-disubstituted amide

Provided is a method for producing glycine, in which on synthesizing glycine from glycinonitrile, glycine can be obtained in a higher yield than that in the conventional method. The present invention relates to a method for producing glycine, including allowing glycinonitrile and water to react with each other in the presence of a cerium compound, optionally adding ammonia thereto, to obtain glycine.

Method for producing glycine

The present invention relates to a method for producing a specified &#x3b1;-amino acid, the method including allowing a specified &#x3b1;-amino acid amide and water to react with each other in the presence of a zirconium compound which contains zirconium and at least one metal element selected from the group consisting of lithium, nickel, copper, zinc, cesium, barium, hafnium, tantalum, cerium, and dysprosium.

Method for producing alpha-amino acid

An ene-thiol based curable composition according to the present invention includes: In the following general formula (1), each of Rand Rindependently represents a hydrogen atom, an alkyl group having 1 to 10 carbon atoms, or an aromatic group having 6 to 10 carbon atoms; a is an integer of 0 to 2; and b is 0 or 1. 

Ene-thiol-type curable composition and cured product thereof

Provided are hair processing agents capable of permanent waving hair even at a neutral to weakly acidic pH range that causes less irritation to the skin, and hair processing agents in which an unpleasant odor is masked. Hair processing agents contain at least one compound represented by the formula (2). Hair processing agents contain a compound of the formula (2) and at least one compound (ii) selected from thioglycolic acid, thiolactic acid, cysteine, acetylcysteine, cysteamine, acylcysteamine, salts thereof and ester derivatives thereof. Hair processing agents contain a compound of the formula (2), a surfactant and water, and are emulsified. Hair processing agents contain a compound of the formula (2) and a specific perfume. wherein X is a structure selected from &#x2014;O&#x2014;, &#x2014;S&#x2014;, &#x2014;NH&#x2014; and &#x2014;NR&#x2014;; Ris an alkyl group of 1 to 6 carbon atoms; Y is an oxygen atom or a sulfur atom; in the formula (1), Z is a divalent organic residue having at least one mercapto group; in the formula (2), R is a divalent organic residue optionally having a mercapto group; and Ris a hydrogen atom or an alkyl group of 1 to 6 carbon atoms. 

Hair processing agent and method for permanent waving hair

An object of the present invention is to provide a method for industrially producing &#x3b2;-mercapto carboxylic acids that are useful as synthetic raw materials for medicines and agrochemicals or as additives for polymer compounds from easily available &#x3b1;,&#x3b2;-unsaturated carboxylic acids in high yields and productivity. The present invention is characterized in that a solvent having an amide group and represented by the formula (1) is used when the &#x3b1;,&#x3b2;-unsaturated carboxylic acids are reacted with hydrogen sulfides to produce the &#x3b2;-mercapto carboxylic acids. Particularly, it is more preferable to carry out the reaction at a pH range of 6.0 to 8.5: (In the formula (1), Rrepresents any one of a hydrogen atom, an alkoxy group having 1 to 5 carbon atoms, an alkyl group having 1 to 5 carbon atoms, an amino group, and an alkylamino group having 1 to 5 carbon atoms; Rand Reach represents independently any one of a hydrogen atom and an alkyl group having 1 to 5 carbon atoms; when both Rand Rare not a hydrogen atom, Rand Rmay together form a ring structure through an alkylene group; and when both Rand Rare not a hydrogen atom, Rand Rmay form a ring structure through an alkylene group).

Method for producing &#x3b2;-mercapto carboxylic acids

Disclosed is an agent for permanent hair waving that can realize permanent hair waving even in the neutral to weakly acidic pH range in which irritation particularly to the skin is not significant. The agent for permanent hair waving includes at least one heterocyclic mercapto compound represented by formula (1): wherein Rand Reach independently represent a hydrogen atom or an optionally substituted alkyl group having 1 to 5 carbon atoms; X represents &#x2014;O&#x2014;, &#x2014;S&#x2014;, &#x2014;NH&#x2014;, or &#x2014;NR&#x2014;; Rrepresents an alkyl group having 1 to 5 carbon atoms; n is an integer of 0 to 2; and, when n is 2, group SH may be attached to any carbon atom of an alkylene group having 2 carbon atoms.

Agent for permanent hair waving containing heterocyclic mercapto compound

The object of the present invention is to produce a 5-alkyl-oxazolidin-2,4-dione by an industrially advantageous method. The invention relates to novel process for producing a high-purity 5-alkyl-oxazolidin-2,4-dione comprising the steps of reacting a 2-hydroxycarboxylic acid amide with a carbonic acid ester in the presence of a metal alcoholate, thereby completing the reaction in one step, and then isolating the reaction product by a neutralization crystallization method.

Production process for 5-alkyl-oxazolidin-2,4-dione

(1) Methods for producing isochromanone compounds from o-xylene compounds as starting compounds through &agr;-halogeno-o-xylene derivatives, &agr;-cyano-o-xylene derivatives, and &agr;-halogeno-&agr;&prime;-cyano-o-xylene derivatives, and (2) methods for producing isochromanone compounds from o-xylene compounds as starting compounds through &agr;,&agr;&prime;-dihalogeno-o-xylene derivatives, &agr;,&agr;&prime;-dihydroxy-o-xylene derivatives, &agr;-halogeno-&agr;&prime;-hydroxy-o-xylene derivatives and &agr;-cyano-&agr;&prime;-hydroxy-o-xylene derivatives, and methods for producing these intermediate compounds.

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Kawasaki, Japan

Akira Shibuya