Kyowa Hakko Kogyo Co., Ltd.

Kyowa Hakko Kogyo Kabushiki Kaisha

Sun Automobile Corporation

Akira Sato

Makoto Morimoto

Tadashi Ashizawa

Tadashi Hirata

Hiromitsu Saito

Masaji Kasai

Yoichi Uosaki

Takehiro Ogasa

Yukio Hashimoto

Seigo Takasawa

Kiyoshi Sato

Shigeru Kobayashi

Jun Suzuki

Hiroshi Sano

Yutaka Saito

Chikara Murakata

Shiro Akinaga

Kunikatsu Shirahata

Eiji Kobayashi

Motomichi Kono

Nobuhiro Nakamizo

An engine ground system for increasing the potential of an engine. This is an engine ground system wherein intermediate portions of a ground wire one end of which is electrically connected to the negative electrode terminal of a battery are electrically connected to engine ground points and the other end of the ground wire is grounded to the car body. The engine ground points can be an engine cylinder head, an intake manifold clamping member, a cylinder head cover, and a throttle body (). Further, a plug cap ground wire is connected between the plug cap clamping member and the intake manifold clamping member.

Engine ground system

Disclosed are DC-52 derivatives represented by the formula: ##STR1## wherein each of R.sup.1 and R.sup.2 independently represents hydrogen or hydroxyl, X represents hydroxyl and Y represents cyano and Z represents carboxyl or hydroxymethyl, or pharmacologically acceptable salts thereof. The DC-52 derivatives are useful as antitumor agents.

DC-52 derivatives

The present invention relates to novel derivatives of DC-52 represented by the following formula (I): ##STR1## [wherein X is chlorine, bromine, iodine, hydroxyl, formyl, hydroxyiminomethyl, cyano, nitro, amino or lower alkanoylamino; and Y is hydroxyl and Z is cyano, or Y and Z represent --O-- in the form of --Y--Z--]. These compounds and pharmacologically acceptable salts thereof have high anti-tumor activity.

Anti-tumor DC-52 derivatives

Anti-tumor DC-52 compounds

A K-252 compound represented by the formula: ##STR1## wherein R.sup.1 and R.sup.2 are independently H or OH; X represents COOH, COOR or CH.sub.2 OH; Y represents H, R or COR; and Z represents OH, OR or SR, wherein R represents lower alkyl has C-kinase inhibitory activity and is expected to be useful as an active ingredient of anti-tumor agents, etc.

K-252 compounds

Compounds represented by the following formula or by the corresponding hydroquinone type formula: ##STR1## in which R.sup.1 and R.sup.2 are independently hydrogen, lower alkoxy, azido, amino, lower alkylamino, di-lower alkylamino, cyclic amino, lower alkylthio or unsubstituted or substituted arylthio; and X represents hydroxyl and Y represents cyano or X and Y together represents --O-- in the form of --X--Y--, have an excellent antitumor activity.

DC-52 derivatives and their antitumor use

Mitomycin derivatives of the formula: ##STR1## wherein X is ##STR2## [wherein R.sub.3 is alkyl, cycloalkyl or optionally substituted phenyl; and R.sub.4 is alkyl or cycloalkyl]; n is an integer of 2 to 8; one of R.sub.1 and R.sub.2 is a hydrogen atom and the other is a carbamoyloxymethyl group, or alternatively R.sub.1 and R.sub.2 may be combined together to form a methylene group (.dbd.CH.sub.2); and Y and Z independently represent hydrogen or methyl; exhibit anti-bacterial and anti-tumor activities.

Mitomycin derivatives having anti-tumor and antibacterial utility

Optically active cephalosporin analogs of the formula ##STR1## wherein R.sub.2 represents a hydrogen or a group represented by the formula ##STR2## wherein R.sub.3 is a straight or branched lower alkyl group having 1 to 6 carbon atoms, a straight or branched lower alkoxy group having 1 to 6 carbon atoms or a phenyl group and R.sub.4 is a hydrogen or a straight or branched lower alkyl group having 1 to 6 carbon atoms; and A.sub.2 represents a straight or branched lower alkyl group having 1 to 6 carbon atoms or a straight or branched lower alkyl group having 1 to 6 carbon atoms which is substituted with one or two carboxyl groups, are useful as antibacterial agents.

Optically active cephalosporin analogs

A 2-azetidinone of formula (I): ##STR1## wherein R.sub.1 represents an aralkoxy, acyloxy, sulphonyloxy or amino group any of which may be substituted, or hydrogen, hydroxy, alkoxy or azido;

2-Azetidinone 4-carboxy derivatives and a process for producing the same

Disclosed are optically active cephalosporin analogs which are produced by optically selective deacylation of an optically inactive acylated analog. The compounds are useful as intermediates in the preparation of optically active acylated antimicrobial agents.

Growing community of inventors

Machida, Japan

Akira Sato