Sumitomo Pharmaceuticals Company Limited

Dainippon Sumitomo Pharma Co., Ltd.

Sumitomo Chemical Company, Limited

National Institute of Advanced Industrial Science and Technology

Akira Sasaki

Makoto Sunagawa

Haruki Matsumura

Koshiro Goda

Tsuneo Yano

Shinzi Takata

Michihiro Yamamoto

Shiro Terashima

Tamejiro Hiyama

Kunikazu Sakai

Katsumi Tamoto

Masatomo Fukasawa

Masao Enomoto

Seiji Hori

Hiroshi Yamaga

Takashi Katsumata

Yoshikazu Kimura

Yoshio Ito

Hiroshi Nouda

Yoshihito Nozaki

Kiyoshi Yoshinaka

Takeo Kawabata

Hideyuki Harada

Naomi Tsushima

Provided is an ultrasound therapy system for treating a joint by providing a focused ultrasound wave to a bone surface as an affected part, and which has a temperature monitoring function for controlling irradiation intensity. The ultrasound therapy system includes a focused ultrasound wave providing unit provided on skin and configured to radiate the focused ultrasound wave to the affected part, and a temperature detecting unit configured to measure a temperature of the affected part. The temperature detecting unit includes an electromagnetic wave measuring unit configured to measure intensity of an electromagnetic wave radiated from the bone surface, and an analyzing unit configured to analyze change of the electromagnetic wave of the electromagnetic wave measuring unit to provide the temperature of the affected part. The analyzing unit provides the temperature of the affected part from electromagnetic change between a pair of reference waves for electromagnetic change which correspond to a pair of an emitted wave of the focused ultrasound wave provided from the focused ultrasound wave providing unit and a reflected wave from the bone surface and which are measured at the electromagnetic wave measuring unit with a time delay.

Ultrasound therapy system

Carbapenem compounds represented by the general formula [1] or pharmaceutically acceptable salts thereof: wherein Ris C-Calkyl or hydroxylated C-Calkyl, R is hydrogen atom or a group which is hydrolyzed in vivo into a carboxy group, and G is a group represented by one of the formulae [G1], [G2], and [G3]. 

Carbapenem compounds

A compound or its pharmaceutically acceptable salt represented by the following formula: The invention is a carbapenem compound which has a potent antibacterial activity over a broad range of Gram negative and Gram positive bacteria, especially penicillin-resistant(PRSP) which has been isolated at an elevated frequency in recent years and thus causes a serious clinical problem, andwhich has acquired resistance against the existing &#x3b2;-lactam antibiotics over a wide scope due to penicillin-binding protein (PBP) mutations such as &#x3b2;-lactamase non-producing ampicillin-resistant (BLNAR), and has excellent oral absorbability.

Carbapenem compounds having a substituted phenyl or a substituted thienyl directly attached to the-position of carbapenem nucleus as represented by the formula: wherein Ring E is benzene ring or thiophene ring; Ris optionally OH-substituted Calkyl; Rand Rrepresent each H, optionally substituted lower alkyl, etc.; R is H, or a group which is hydrolyzed in the living body to regenerate a carboxyl group, etc.; X is O or S; and Y represents H, lower alkyl, etc., or pharmaceutically acceptable salts thereof and medicaments containing said compound as the active ingredient. These compounds exhibit an excellent antibacterial activity over a broad range of Gram-positive and Gram-negative bacteria, in particular, penicillin-resistant(PRSP) which has been isolated at an elevated frequency in recent years and thus causes a serious clinical problem, andwhich has acquired resistance against the existing &#x3b2;-lactam antibiotics over a wide scope due to penicillin-binding protein (PBP) mutations such as &#x3b2;-lactamase non-producing ampicillin-resistant (BLNAR)

Estrogen derivative having carriers to bone

A beta-lactam compound of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are, the same or different, each a hydrogen atom or a lower alkyl group, R.sub.3.sup.o is a lower alkyl group having a beta-configuration, R.sub.4 is a carboxyl-protecting group, X is a hydrogen atom or a protected hydroxyl group and COZ is a protected thiolcarboxyl group, which is useful as a valuable intermediate in the stereospecific production of 1-alkylcarbapenem compounds.

Beta-lactams and their production

A beta-lactam compound of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are, the same or different, each a hydrogen atom or a lower alkyl group, R.sub.3.sup.0 is a hydroen atom or a lower alkyl group having a beta-configuration, R.sub.4 is a carboxyl-protecting group, X is a hydrogen atom or a protected hydroxyl group and COZ is a protected thiolcarboxyl group, which is useful as a valuable intermediate in the stereospecific production of 1-alkylcarbapenem compounds.

A compound of the formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each a hydrogen atom, a lower alkyl group, an ar(lower)alkyl group or an aryl group, or R.sub.1 and R.sub.2 may be combined together to form a lower alkylene group and/or R.sub.3 and R.sub.4 are combined together to form a lower alkylene group, or R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be combined together to form an o-phenylene group, X is a halogen atom and Y is an oxygen atom or a nitrogen atom substituted with lower alkyl or aryl, which is useful as an intermediate in the synthesis of 1.beta.-methylcarbapenem compounds valuable as antibiotics.

Heterocyclic compounds and their production

A compound of the formula: ##STR1## , which is useful as an antimicrobial agent.

.beta.-lactam compounds and their production

An amino acid compound of the formula: ##STR1## wherein R is a lower alkyl group, R.sub.1 is a hydrogen atom or a protecting group for carboxyl, R.sub.2 is a hydrogen atom, a protecting group for amino, an optionally substituted allyl group of the formula: ##STR2## (wherein R.sub.3 and R.sub.4 are each a hydrogen atom, a lower alkyl group or an aryl group), a beta-hydroxyethyl group in which the hydroxyl group is optionally protected, a formylmethyl group in which the formyl group is optionally protected, a carboxymethyl group in which the carboxyl group is protected or a 2-furylmethyl group and X is an optionally protected carboxyl group, a hydroxymethyl group in which the hydroxyl group is optionally protected or a substituted mercaptomethyl group of the formula:

3(1-hydoxyethyl)azetidinone compounds and their production

A beta-lactam compound of the formula: ##STR1## wherein R.sub.1 is a hydrogen atom, a lower alkyl group or a 1-hydroxy(lower)alkyl group wherein the hydroxyl group is optionally protected, R.sub.2 is a hydrogen atom or a protective group for the nitrogen atom and R.sub.3 is a methyl group, a halomethyl group, a hydroxymethyl group, a protected hydroxymethyl group, a formyl group, a carboxyl group, a lower alkoxycarbonyl group or an ar(lower)alkoxycarbonyl group wherein the aryl group is optionally substituted, or R.sub.2 and R.sub.3 are combined together to form an oxaalkylene group and, when taken together with one nitrogen atom and two carbon atoms adjacent thereto, they represent a six-membered cyclic aminoacetal group, which is useful as a valuable intermediate in the stereospecific production of 1-methylcarbapenem compounds.

Beta-lactams

Beta-lactams and their production via stereospecific hydrogenation

.beta.-Lactam compounds which are useful as intermediates for the production of carbapenem or penem derivatives and a process for producing the same. The process comprises reacting a Schiff base with diketene in the presence of an imidazole, reducing the acetyl group of the resulting N-protected-3-acetyl-2-azetidinone-4-carboxylic acid ester, and removing the protecting group for a carboxyl group from the resulting 3-(1-hydroxyethyl)-2-azetidinone-4-carboxylic acid derivative.

Growing community of inventors

Osaka, Japan

Akira Sasaki