Nippon Shinyaku Company, Ltd.

Akira Sano

Koji Kitaguchi

Hiromu Murai

Masahiko Kitano

Toshio Tomita

Tatsuo Suminokura

Yutaka Takahashi

Masahiro Kise

Masanobu Kawamata

Sho Inoue

Kyoichi Ideguchi

Hirokazu Ushimaru

Massahiro Kise

Masakazu Ueno

A method for producing high purity sterol glycosides which is characterized by selecting a most suitable raw material from among raw materials, by making use of free sterols coexistent in said raw materials, as an indication for the selection; extracting a mixture of sterol glycosides from the selected raw material; turning the resulting extract into their tetracetates; thereafter separating an objective fraction alone according to a liquid chromatography; and hydrolyzing this fraction to obtain the original sterol glycosides.

Method for producing high purity sterol glycosides

Sterol glycosides are isolated from sterol glycoside-containing plant material by heating the material in alkaline lower alkanol at elevated temperatures in the presence of an alkali metal carbonate, bicarbonate or nitrate to effect formation and precipitation of a complex which is then isolated.

Method of preparing sterol glycosides from plants

Steryl-6-0-palmitoyl-.beta.-D-glucosides are anti-inflammatory agents. The compounds, of which .beta.-sitosteryl-6-0-palmitoyl-.beta.-D-glucoside is a representative embodiment, are prepared through the reaction of a steryl-6-0-sulfonyl-.beta.-D-glucoside with an alkali metal salt of palmitic acid.

Steryl-.beta.-D-glucoside esters and method of preparation

Steryl-6-O-palnitoyl and -2,3,4,6-O-tetrapalmitoyl-.beta.-D-glucosides are anti-inflammatory agents. The compounds, of which .beta.-sitosteryl-2,3,4,6-O-tetrapalmitoyl-.beta.-D-glucoside is a representative embodiment, are prepared through the reaction of a steryl-.beta.-D-glucoside with a lower alkyl ester of palmitic acid in the presence of a basic catalyst.

Steryl-.beta.-D-glucoside ester pharmaceutical compositions and method

A method of preparing aqueous solutions of sterol glycosides and their ester derivatives characterized by solubilizing sterol glycosides and their ester derivatives by (1) dissolving said sterol glycoside or ester in a lower aliphatic alcohol and subsequently adding a hydrophilic non-ionic surface active agent, or (2) mixing or dissolving said sterol glycoside or ester with or in a lipophilic surface active agent or its solution in an organic solvent miscible with water and subsequently adding a hydrophilic surface active agent.

Method of preparing aqueous solutions of sterol glycosides and their

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Kyoto, Japan

Akira Sano