Nec Corporation

Other

Masahiko Kuroda

Akira Saito

Kenji Okajima

Yoshiko Yamashita

The detection accuracy of poorly differentiated cancers in adenocarcinoma is improved by restricting false detection. Cell nucleus detection meansreceives a digitized pathological image as an input and extracts the region of a cell nucleus therefrom. Gland duct detection meansdetects a gland duct structure in the image. Poorly differentiated cancer detection meansdetects poorly differentiated cancers only in the region other than the gland duct region. False detection rejection meanscompares the detection density of poorly differentiated cancer in the vicinity of a detection point with a threshold that is predetermined depending on gland duct density in the vicinity of the detection point, at each detection point detected by poorly differentiated cancer detection meansand rejects the detection point as a false detection if the detection density of a poorly differentiated cancer is smaller than the threshold.

Module for detecting poorly differentiated cancers and pathological image diagnosis support apparatus, program and recording medium including the same

An evaluation system includes a capture unit for capturing an image of a living tissue in which HER2 protein and cell nucleuses are dyed, a discrimination unit for identifying a cell membrane from the image of the living tissue based on dyed cell nucleuses within the image of the living tissue captured by the capture unit to discriminate a dyed state of the cell membrane, and an evaluation unit for evaluating development of the HER2 protein based on a discrimination result by the discrimination unit.

Evaluation system, evaluation method, and recording medium

The present invention identifies the total nucleotide sequence of a novel oncogene from human, which is directly involved in such a cancerization mechanism as for cervical cancer induced by HPV infection of cervical epithelial cell and the amino acid sequence of an oncogenic protein encoded thereby, and to provide a full-length polynucleotide encoding a peptide chain of the oncogenic protein derived from the novel oncogene, which can be used for recombinant production of the oncogenic protein, and the peptide chain of the oncogenic protein produced recombinantly therewith. Specifically, the present invention provides a novel oncogene polynucleotide from human involving development of cervical cancer, comprising a nucleotide sequence encoding an amino acid sequence of SEQ. ID. No. 1, particularly a polynucleotide of the nucleotide sequence of SEQ. ID. No. 2.

Sirna capable of inhibiting the expression of an oncogene involved in cervical cancer

The present invention identifies the total nucleotide sequence of a novel oncogene from human, which is directly involved in such a cancerization mechanism as for cervical cancer induced by HPV infection of cervical epithelial cell and the amino acid sequence of an oncogenic protein encoded thereby, and to provide a full-length polynucleotide encoding a peptide chain of the oncogenic protein derived from the novel oncogene, which can be used for recombinant production of the oncogenic protein, and the peptide chain of the oncogenic protein produced recombinantly therewith. Specifically, the present invention provides a novel oncogene polynucleotide from human involving development of cervical cancer, comprising a nucleotide sequence encoding an amino acid sequence of SEQ. ID. No.1, particularly a polynucleotide of the nucleotide sequence of SEQ. ID. No.2.

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Minato-ku, Japan

Akira Saito