Kyowa Hakko Kogyo Co., Ltd.

Akira Ogawa

Yuji Nomoto

Kimihisa Ueno

Satoshi Nakanishi

Hideaki Kusaka

Yoshihisa Ohta

Kotaro Takasaki

Hiroshi Yano

Chiharu Nakagawa

A condensed purine derivative represented by Formula (I):wherein X&#x2014;Y-Z represents RN&#x2014;C&#x2550;O or N&#x2550;C&#x2014;W, Rrepresents a hydrogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted aromatic heterocyclic group, a substituted or unsubstituted alicyclic heterocyclic group or the like, n represents an integer of from 0 to 3, Vrepresents a hydrogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted aromatic heterocyclic group, Vrepresents a substituted lower alkyl group or a substituted or unsubstituted aromatic heterocyclic group, and when Vrepresents a hydrogen atom, a lower alkyl group, a substituted or unsubstituted aralkyl group, or a substituted or unsubstituted aryl group, and for example, X&#x2014;Y-Z represents RN&#x2014;C&#x2550;O and Rrepresents a substituted lower alkyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted alicyclic heterocyclic group, a halogen atom, a lower alkylthio group, &#x2014;NRR, &#x2014;COH, a lower alkoxycarbonyl group, &#x2014;COHal, &#x2014;CONRRor &#x2014;CHO, Vmay represent a lower alkyl group, a substituted or unsubstituted aralkyl group, or a substituted or unsubstituted aryl group; or a pharmacologically acceptable salt thereof.

Fused purine derivatives

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Shizuoka, Japan

Akira Ogawa