Toray Industries, Inc.

Kyoto University

Akira Myomoto

Satoko Kozono

Hitoshi Nobumasa

Yoshinori Tanaka

Osamu Ogawa

Gozoh Tsujimoto

Hideo Akiyama

Yutaka Shimada

Osamu Nomura

Shiori Tomoda

Fumiaki Sato

Kazuharu Shimizu

Masakazu Toi

Takayuki Ueno

Zhipeng Wang

Eijiro Nakamura

This invention relates to a composition and a method for prediction of a response to Trastuzumab therapy in a breast cancer patient, and more specifically, a composition, a kit, a DNA chip, and a method for predicting a response to Trastuzumab therapy by using polynucleotides each comprising a nucleotide sequence represented by any of SEQ ID NOs: 1 to 9, 11 to 19, and 21 to 23 in the Sequence Listing or a nucleotide sequence derived therefrom by substitution of u with t, mutants thereof, derivatives thereof, or fragments thereof comprising at least 16 continuous nucleotides, or a polynucleotide comprising a complementary sequence thereof, and using an increase or decrease in Her2 protein expression level as an indicator.

Method for predicting response to trastuzumab therapy in breast cancer patients

This invention relates to a composition, kit, or DNA chip for use in diagnosis of esophageal cancer, which comprises a plurality of polynucleotides selected from the group consisting of polynucleotides whose expression levels are varied in esophageal cancer tissues obtained from esophageal cancer patients when compared with cancer-free esophageal tissues obtained from esophageal cancer patients, mutants thereof, and fragments thereof, and to a method for detecting esophageal cancer using the composition, kit, or DNA chip.

Method for diagnosing esophageal cancer

This invention relates to a composition, kit, or DNA chip comprising polynucleotides and antibodies as probes for detecting, determining, or predicting the presence or metastasis of esophageal cancer, and to a method for detecting, determining, or predicting the presence or metastasis of esophageal cancer using the same.

Growing community of inventors

Kamakura, Japan

Akira Myomoto