Mitsui Petrochemical Industries, Ltd.

Mitsui Toatsu Chemicals, Incorporated

Mitsui Pharmaceuticals, Inc.

Akira Mizuchi

Kazutoshi Horikomi

Akira Awaya

Ikuo Tomino

Noriaki Kihara

Akira Matsubara

Kazuya Sakai

Hideki Tanada

Tadayuki Sasaki

Seitaro Kajiya

Takumi Kitahara

Norio Ohto

Hideshi Shimizu

Keiichi Yokoyama

Takuo Nakano

Mitsuyuki Takesue

Masaharu Ishiguro

Ken Ikeda

Joji Kamiya

Masaaki Ishii

Hisashi Kobayashi

Shintaro Araki

Koji Kato

Kanji Yoshihara

Takuma Ohtsu

Yuichiro Kokubun

Aminoketone derivative compounds containing a heterocyclic ring bonded to an aminoketone moiety and useful as effective ingredients of centrally acting muscle relaxants and pollakiurea curing agents. (+)3-phenyl-5-[2-(1-pyrrolidinylmethyl)butyryl] isoxazole, which has a more remarkable central muscle relaxant action as compared with its racemic modification, can be effectively separated from the racemic modification using optically active 10-camphorsulfonic acid as the agent for the optical resolution.

Aminoketone derivatives and use thereof

Aminoketone derivative compounds containing a heterocyclic ring bonded to an aminoketone moiety and useful as effective ingredients of centrally acting muscle relaxants and pollakiurea curing agents. (+)3-phenyl-5-[2-(1-pyrrolidinylmethyl)butyryl]isoxazole, which has a more remarkable central muscle relaxant action as compared with its racemic modification, can be effectively separated from the racemic modification using optically active 10-camphorsulfonic acid as the agent for the optical resolution.

Aminoketone derivative and use thereof

Pyrimidine compound and pharmaceutically acceptable salts thereof

Aminoketone derivatives of 1,2-oxazole and use thereof

This invention provides novel pyrimidines or their pharmaceutically acceptable salts thereof and process for preparation thereof. The novel compounds are useful for neurological diseases of the peripheral and central nervous systems of animals.

Pyrimidines and pharmaceutically acceptable salts thereof useful in

2,6-di-, 2,4,6-, 2,5,6-tri- or 2,4,5,6-tetra-substituted pyrimidines, and 2,6-di-substituted pyridines. These compounds are useful for treatment of neurological deseases.

Pyrimidines and their pharmaceutical acceptable salts, and their use as

Amine represented by the following formula (1), or their acid addition salts or their quaternary ammonium salts. ##STR1## The amines of formula (1) or their pharmaceutically acceptable acid addition salts or quaternary ammonium salts are useful for the treatment and prevention of heart diseases of animals, particularly arrhythima, myocardial infarction, angina pectoris and heart failure and psychoneurological diseases.

Coumaran group containing amine compounds and their acid addition salts

2,6-di-, 2,4,6-, 2,5,6-tri- or 2,4,5,6-tetra-substituted pyrimidines, and 2,6-di-substituted pyridines. These compounds are useful for treatment of neurological diseases.

2,6-di,2,4,6-, 2,5,6-tri and 2,4,5,6-tetra-substituted pyrimidines,

Described herein are imidazole derivatives having a specific structure and satisfactory as antiepileptics from the standpoint of the strength of action, prolonged action and side effects as well as their preparation processes.

Imidazole derivatives and antiepileptics comprising said imidazole

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Mobara, Japan

Akira Mizuchi