Shionogi Company Limited

Purdue Pharma L.p.

Aida Engineering Co., Ltd.

Akira Matsumura

Naoki Tsuno

Hidenori Mikamiyama

Kazuto Kobayashi

Hisanobu Kanamaru

Jiangchao Yao

Moriyasu Masui

Bin Shao

Yoshinori Tamura

Toshiyuki Akiyama

Shuichi Sugiyama

Yutaka Tomida

R Richard Goehring

Yoshiyuki Taoda

Makoto Adachi

Nobuyuki Ishinaga

Kouki Fuchino

John W F Whitehead

Kosuke Anan

John William Frank Whitehead

Kayoko Hata

The present invention provides a novel compound having antiviral activity, especially HIV replication inhibitory activity and a medicament containing the same. The compound represented by the formula: wherein Ais CR, CRR, N or NR; R, R, Rand Rare each independently a hydrogen atom, halogen, cyano, substituted or unsubstituted alkyl, substituted or unsubstituted alkynyl, or substituted or unsubstituted non-aromatic carbocyclyl; Ris a hydrogen atom, substituted or unsubstituted alkyl, or substituted or unsubstituted non-aromatic carbocyclyl; ring Tis substituted or unsubstituted nitrogen-containing non-aromatic heterocycle; Ris a hydrogen atom, halogen, cyano, or substituted or unsubstituted alkyl; Ris each independently substituted or unsubstituted alkyl or the like: n is 1 or 2; Ris substituted or unsubstituted aromatic carbocyclyl or the like; Ris a hydrogen atom or a carboxy protecting group.

Nitrogen-containing tricyclic derivatives having HIV replication inhibitory activity

The invention relates to Substituted-Quinoxaline-Type Piperidine Compounds, compositions comprising an effective amount of a Substituted-Quinoxaline-Type Piperidine Compound and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Substituted-Quinoxaline-Type Piperidine Compound.

Substituted-quinoxaline-type piperidine compounds and the uses thereof

The invention relates to azetidinyl, pyrrolidinyl, piperidinyl, and hexahydroazepinyl compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R-R, Z, p and q are defined as set forth in the specification. The invention is also directed to the use compounds of Formula (I) to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain. 

Benzenesulfonamide compounds and the use thereof

The invention relates to acrylamide compounds of Formula I mentioned below. The invention is also directed to the use compounds of Formula I to treat or prevent a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain. 

Acrylamide compounds and the use thereof

It was found out that the nitrogen-containing heterocyclic derivative represented by the formula (I) specifically binds to a receptor of NR1/NR2B, and is used as a NR2B receptor antagonist. A compound represented by: wherein Z is N or CR, Ais a nitrogen-containing aromatic monocyclic group which is optionally substituted, a nitrogen-containing aromatic fused cyclic group which is optionally substituted etc., Ais an aromatic hydrocarbon cyclic group or an aromatic heterocyclic group, each optionally having a substituent, R, R, R, R, Rand Rare each independently hydrogen, hydroxy, etc., w is 2 or 3, t is 1 or 2, X is &#x2014;(CRR)m-, &#x2014;CO(CRR)n-, &#x2014;CONR(CRR)n- etc., m is an integer of 1 to 4, n is an integer of 0 to 4, Rand Rare each independently hydrogen, halogen, hydroxy etc., and Ris hydrogen or lower alkyl,or a pharmaceutically acceptable salt, or a solvate thereof.

Nitrogen-containing heterocycle derivatives substituted with cyclic group

A groove is cut into an end surface of a shaft component to deform the shaft component into irregularities provided on a tubular component, thereby coupling the shaft component with the tubular component to form an outer ring for a constant velocity joint. This type of joint provides an outer ring having a strong coupling force and high coupling precision. The irregularities are preferably in the form of a spline cut in a portion of an inner perimeter surface of the tubular component, at a location where coupling of the tubular component with the shaft component is desired. The spline optionally includes a notch which provided additional coupling strength, especially in the shaft direction. The tubular component is shaped by pressing the inner surface of the tubular component into a mandrel having an outer surface shape of the desired inner surface shape of the tubular component. Hydraulic pressure is used to supply the force to press the material onto the mandrel to form the tubular component. This shaping method results in a molded material with high precision without requiring bond treatment.

Outer ring of a constant velocity universal joint and manufacturing method for the same

A molding method uses a fluid-pressure generating unit form generating high fluid pressures that allows high-precision molding of complex shapes. The high fluid pressure is generated with a piston disposed in communication with a molding cavity. The high fluid pressure is imposed on a raw material workpiece to push the workpiece into a cavity causing the workpiece to conform to the shape of the cavity thereby producing an article of desired shape.

Method for molding metal using high fluid pressure

Growing community of inventors

Osaka, Japan

Akira Matsumura