Sony Corporation

Toray Industries, Inc.

Akira Kurihara

Isao Kawashima

Yoshitomo Osawa

Yoichiro Sako

Hideo Owa

Fumiyoshi Okano

Naomi Go

Shozo Masuda

Shinobu Kuriya

Shigeyuki Yoneyama

Yoji Kawamoto

Norihiro Nagai

Masao Morita

Hideo Tsukazaki

Kotaro Asaka

Yoshimichi Kitaya

Takayuki Fujita

Toshiharu Fukui

Haruhiko Kishi

Hideki Nomura

Naomi Urano

Hyongi Chon

An object of the present invention is to discover a novel peptide useful as an active ingredient in an agent for treating or preventing cancer, and to provide the use of the polypeptide as an immune inducer. The immune inducer contains as an active ingredient, the following (i) or (ii): (i) at least one polypeptide having an immune-inducing activity and selected from the group of polypeptides (a) or (b), where: (a) polypeptides consisting of 7 or more consecutive amino acids within the region of positions 24 to 97 in the amino acid sequence represented by SEQ ID NO: 2; and (b) polypeptides comprising one to several amino acid deletions, substitutions and/or additions in the amino acid sequence of any one of the polypeptides (a); and (ii) a recombinant vector comprising at least one polynucleotide encoding any one of the polypeptides, and capable of expressing the polypeptide in vivo.

Immune inducer

This application provides an immunity-inducing agent comprising, as an active ingredient, at least one polypeptide having immunity-inducing activity and selected from (a) polypeptides consisting of amino acid sequences represented by SEQ ID NO: 8, 4, 6, 10, 12, 2 and 14, and polypeptides consisting of 7 or more consecutive amino acids in the amino acid sequences, (b) polypeptides having a sequence identity of 85% or more with the amino acid sequences represented by SEQ ID NO: 8, 4, 6, 10, 12, 2 and 14, and polypeptides consisting of 7 or more consecutive amino acids in the amino acid sequences, and (c) polypeptides comprising the polypeptides according to (a) or (b) as the partial sequences, or a recombinant vector comprising a polynucleotide encoding the polypeptide and capable of expressing the polypeptide in vivo.

Immunity-inducing agent

The present invention addresses the problem of finding a novel peptide useful as an active ingredient in an agent for treating or preventing cancer, and to provide the use of the polypeptide as an immune inducer. The immune inducer containing as an active ingredient: (a) a polypeptide consisting of any one of the amino acid sequences represented by SEQ ID NOs: 3 to 45; or (b) a polypeptide comprising one to several amino acid deletions, substitutions or additions in the amino acid sequence of the polypeptide (a); is useful as an agent for treating or preventing cancer, etc.

Immunogenic peptides of SCD1 protein

An object of the present invention is to identify a cancer antigen protein specifically expressed on the surface of cancer cells and provide use of an antibody targeting the cancer antigen protein as a therapeutic and/or prophylactic agent for cancer. A pharmaceutical composition for treating and/or preventing cancer comprising an antibody or a fragment thereof having immunological reactivity with CSPG5 protein consisting of any one of amino acid sequences represented by SEQ ID NOs: 8, 4, 6, 10, and 12 and an amino acid sequence having an amino acid identity of 80% or more to the amino acid sequence, or a fragment thereof consisting of 7 or more consecutive amino acids, as an active ingredient.

Pharmaceutical composition for treating and/or preventing cancer

Provided is a method for inducing immunity for therapy of a cancer(s). The method includes the step of administering to an individual with cancer at least one polypeptide selected from the polypeptides (a) or (b) below, and/or a recombinant vector(s) that comprise(s) a polynucleotide(s) encoding the at least one polypeptide, the recombinant vector(s) being capable of expressing the polypeptide(s) in vivo: (a) a polypeptide in any one of the amino acid sequences of SEQ ID NOs: 2, 4, 22, or 24; and (b) a polypeptide having a sequence identity of not less than 95% to the polypeptide (a). Further, an in vitro method for preparing an antigen-presenting cell is provided. The method includes the step of contacting the antigen-presenting cell with the at least one polypeptide selected from: (a) a polypeptide in any one of the amino acid sequences of SEQ ID NOs: 2, 4, 22, or 24; and (b) a polypeptide having a sequence identity of not less than 95% to the polypeptide (a).

Immunity induction agent

Provided is a method for inducing immunity for therapy of a cancer(s). The method includes the step of administering to an individual with cancer at least one polypeptide selected from the polypeptides (a) or (b) below, and/or a recombinant vector(s) that comprise(s) a polynucleotide(s) encoding the at least one polypeptide, the recombinant vector(s) being capable of expressing the polypeptide(s) in vivo: (a) a polypeptide in any one of the amino acid sequences of SEQ ID NOs: 2, 4, 8, 10 and 12; and (b) a polypeptide having a sequence identity of not less than 95% to the polypeptide (a).

Immunity inducing agent

An immunity-inducing agent comprising as an effective ingredient(s) a polypeptide(s) selected from the polypeptides: (a) a polypeptide consisting essentially of not less than 7 consecutive amino acids in any one of the amino acid sequences shown in SEQ ID NOs:2, 4, 6, 8, 10, 12 and 44 in SEQUENCE LISTING; (b) a polypeptide having a sequence identity of not less than 90% with the polypeptide (a) and consisting essentially of not less than 7 amino acids; and (c) a polypeptide comprising the polypeptide (a) or (b) as a partial sequence thereof; which polypeptide(s) has/have an immunity-inducing activity/activities, or as an effective ingredient(s) a recombinant vector(s) which comprise(s) a polynucleotide(s) encoding the polypeptide(s) and is/are capable of expressing the polypeptide(s) in vivo, is useful as a therapeutic and/or prophylactic agent for cancer, and/or the like.

Disclosed is an information providing apparatus comprising first reception control means for controlling the reception, from a first information processing apparatus, of user identification data for identifying a user of the first information processing apparatus and a request for purchasing a content, first transmission control means for controlling in response to the request for purchasing the content the transmission of the request for purchasing the content to a second information processing apparatus, second reception control means for controlling the reception of the content and usage conditions thereof supplied from the second information processing apparatus, storage control means for controlling the storing of the content and usage conditions thereof in correlation with the user identification data, third reception control means for controlling the reception of the user identification data and a request for sending the content supplied from the first information processing apparatus, and second transmission control means for controlling, in response to the request for sending the content, the transmission of the content stored in correlation with the user identification data.

Information providing apparatus and method, information processing apparatus and method, program storage medium, program, and information providing system

A signal recording/reproducing method and apparatus, signal record medium and signal transmission/reception method and apparatus, whereby a signal recorded on a signal record medium can be identified as being an original signal or a copied signal. A CPUgenerates, at a pre-set time interval, an identification signal having a meaning at a pre-set time interval, and an identification signal addition circuitadds the identification signal to the video signals and/or the audio signals. A sector forming circuitand circuit components up to a recording/reproducing headrecord the video signals and/or the audio signals and the ancillary identification signal on an optical disc

Signal recording/reproducing method and apparatus, signal record medium and signal transmission/reception method and apparatus

The present invention relates to an information processing apparatus by which a communication channel providing a high degree of privacy is established between a PDA and a data communication server. Data encrypted with a temporary key is shared by a PDA and a memory card. The memory card decrypts the data by the shared temporary key, and then stores the data in the memory card. Data encrypted with a temporary key shared by a PC and the memory card. The PC decrypts the data by the shared temporary key, and then stores the data in the PC. The PC and the data communication server are connected to each other, and perform mutual authentication. The data encrypted with a temporary key shared by the PC and the data communication server as a result of the authentication is transmitted from the PC to the data communication server via a broadband network.

Information processing apparatus and method, recording medium, and program

An authentication function authenticates a PDA. The content database holds the usage conditions of a content and the information about the content. The communication function controls the reception of the usage conditions and the content information, both transmitted from the PDA. The content management function updates the usage conditions and the content information received, on the basis of the usage conditions and the content information held. The desired content is thereby retrieved quickly.

Information providing apparatus and information providing method

The present invention relates to a content-providing system, information-processing apparatus, information-processing methods and programs which are capable of keeping up with changes in content value. A license servertransmits a utilization condition and a price table to a terminal. The terminalhas set contents stored in advance in a database. In an offline environment, the terminalis capable of utilizing desired contents by using an electronic point count. The terminaltransmits information on contents used by the terminalto the license server. The license servercollects a history of utilizations of contents in the terminal, extracts apparatus favorite contents for the terminalfrom a database and properly transmits the favorite contents as well as price data reflecting changes in price to the terminal. The present invention is thus suitable for a system for providing contents.

Content providing system, information processing device and method, and program

A signal transmission method applicable to prevention of modification or alteration of the playback mode information, such as copying management information or charging information. The playback mode information form a terminal is data-converted for ciphering by a playback mode information appendage circuit in a header appendage circuit responsive to the key information from a terminal and the resulting information comprised of the data and the playback mode information is outputted. The reproducing side effects data conversion on the ciphered playback mode information for deciphering, by a playback mode information detection circuit in a header separation circuit, using the key information from a terminal, for taking out the original playback mode information at a terminal.

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Kanagawa, Japan

Akira Kurihara