Yamasa Shoyu Kabushiki Kaisha

Other

Yamasu Shoyu Kabushiki Kaisha

Akira Kuninaka

Hitoshi Kusakabe

Kenjiro Kodama

Kenji Soda

Haruhiko Machida

Yuichiro Midorikawa

Michio Ui

Hiroshi Yoshino

Junichi Takezawa

Miyuki Honma

Yuichirow Midorikawa

Haruo Misono

Mineo Saneyoshi

Tomokazu Satoh

An antitumor composition comprising a pharmacologically effective quantity of an ester of 1-.beta.-D-arabinofuranosylcytosine-5'-phosphate represented by the general formula ##STR1## where R is a monovalent aliphatic hydrocarbon group having 14 to 23 carbon atoms, and A designates a hydrogen atom or a pharmaceutically-acceptable alkali cation, and a vehicle is effective when administered by a non-injection method, particularly orally.

Antitumor compositions for non-injection administration

An L-lysine .alpha.-oxidase, that is, a novel L-amino acid oxidase having very high substrate-specificity to L-lysine is produced by culturing a specific microorganism belonging to Trichoderma in a medium.

L-Lysine .alpha.-oxidase

L-lysine contained in a sample can be efficiently determined by using the L-lysine .alpha.-oxidase. The preferred enzyme is an L-lysine .alpha.-oxidase, that is, a novel L-amino acid oxidase having very high substrate-specificity to L-lysine is produced by culturing a specific microorganism belonging to Trichoderma in a medium.

Assay of L-lysine

An assay kit for assaying adenosine-3',5'-cyclic monophosphate, which is herein referred to as cAMP, guanosine-3',5'-cyclic monophosphate, which is herein referred to as a cGMP, or both; and said assay kit comprising,

Assay kit for cAMP and/or cGMP and method of using the same

The enzyme pterin deaminase may be used as an antitumor agent, and can be produced from cultures of the fungal genera Aspergillus, Mucor, Rhizopus, and Penicillium.

Process for producing pterin deaminases having antitumor activity

Growing community of inventors

Choshi, Japan

Akira Kuninaka