Kaneka Corporation

Matsushita Electric Industrial Co., Ltd.

Hokkaido University

National Cerebral and Cardiovascular Center

Hyogo College of Medicine

Foundation for Biomedical Research and Innovation at Kobe

Nippon Steel Sumitomo Metal Corporation

Akira Kobayashi

Masaru Nakatani

Shinya Yoshida

Hideo Niwa

Masaki Ichimura

Naohiro Imai

Masaharu Ueda

Yoshiaki Miyamoto

Haruhiko Yokoyama

Akihiko Taguchi

Hirokazu Kurata

Kenichi Yamahara

Toshihiro Soma

Shunsuke Ohnishi

Kazuaki Yamamoto

Nobuhiko Sato

Hiroshi Awaji

Shigeo Furuyoshi

Takashi Morohoshi

Kazumasa Okumura

Junichi Hada

Kinji Horikami

Seiji Mizuoka

Satoshi Takata

Yoshihiro Itsuzaki

Noriyuki Suzuki

Takuya Tanahashi

Yoshinobu Kishimoto

Hideshi Ueda

Takehiro Nishimoto

Tsuyoshi Nomura

Kunihito Mori

Masatatsu Nakamura

Katsuya Iwano

Tsutomu Okuyama

Koji Fujita

Masatoshi Nakamura

Nobutaka Taira

Hidesi Ueda

Katsuo Noguchi

Noriko Tokuda

Hideo Kano

Ashutosh Kumar

Kouji Yoshii

Yukinobu Ohmichi

Ryoichi Inoue

Jun Takahashi

Koichiro Matsushita

Kazuo Fujita

Koichi Uchino

An object of the present invention is to provide a method for producing a mesenchymal stromal cell composition, comprising conveniently and aseptically separating high-purity amnion-derived MSCs by performing enzyme treatment only once. According to the present invention, the following are provided: a method for producing a mesenchymal stromal cell composition, comprising: performing enzyme treatment of an amnion with collagenase and thermolysin and/or dispase; and filtering the enzyme-treated amnion through a mesh; a method for producing a cryopreserved mesenchymal stromal cell composition; and a therapeutic agent comprising as an active ingredient the mesenchymal stromal cell composition for a disease selected from graft-versus-host disease, inflammatory bowel disease, systemic lupus erythematosus, liver cirrhosis, or radiation enteritis.

Method for producing amniotic mesenchymal stromal cell composition, method for cryopreserving the same, and therapeutic agent

The present invention has its object to provide a material for separating stem cell and a filter for separating stem cell, each is capable of selectively separating and recovering, in a simple and easy manner, stem cells from body fluids or biological tissue-derived treated fluids, a method for separating and recovering stem cells, and stem cells obtained by such method. The present invention is a material for separating stem cell which has a density K of 1.0&#xd7;10&#x2266;K&#x2266;1.0&#xd7;10and a fiber diameter of 3 to 40 &#x3bc;m; a filter for separating stem cell which comprises the material for separating stem cell as packed in a container having a fluid inlet port and a fluid outlet port; a method of separating and recovering stem cells which comprises using the material for separating stem cell or the filter for separating stem cell; and a method of producing a multipotent cell fraction.

Stem cell separating material and method of separation

The present invention relates to a separation system and a separation material for easily and rapidly separating a red blood cell-rich fraction, a white blood cell-rich fraction, and/or a platelet-rich fraction from a biological fluid containing these blood cell components without the necessity of performing centrifugation. The separation of a red blood cell-rich fraction, a white blood cell-rich fraction, and/or a platelet-rich fraction from a biological fluid can be accomplished by capturing white blood cells and platelets on a blood cell separation material by contacting the biological fluid with the blood cell separation material, thereby providing a red blood cell-rich fraction; and recovering a white blood cell-rich fraction by separating white blood cells captured from the resulting blood cell separation material using a separation solution.

Blood component separation system and separation material

It is an object to achieve a closed system that has a simple structure without resorting to large scale equipment and that sequentially carries out all of the step of separating useful cells, the step of culturing the useful cells separated in the separation step, and the step of washing and concentrating the cells cultured in the culturing step and to enable the preparation of useful cells having high safety and quality, while improving operability. A disposable set for cell culture includes a cell culture container (CC) having a liquid inlet (Lin) and a liquid outlet (Lout), a cell separation kit (A) that is for separating cells used for cell culture and is connected to the liquid inlet (Lin), and a cell collection kit (B) that is for washing and concentrating cultured cells in the cell culture container (CC) and is connected to the liquid outlet (Lout), and a cell culture device uses the disposable set for cell culture and includes flow path on-off valves and pumps provided at appropriate positions of pipelines of the disposable set and a controller controlling them.

Disposable set for cell culture, cell culture device and cell preparation method

The invention relates to a porous material for body fluid treatment for promoting lymphocyte proliferation in lymphocyte culture which contains a high-molecular compound having an angle of contact with water within the range of 40 to 98&#xb0;, and a porous material for body fluid treatment which comprises activated carbon; and also relates to a treatment device wherein the porous material is used; a method for proliferating lymphocytes; a method for producing mammalian lymphocytes; a method for producing a pharmaceutical composition; an additive body fluid to be added to a culture medium on the occasion of lymphocyte culture; a method for treating a disease against which a therapeutic effect is produced by returning extracorporeally activated mammalian lymphocytes into the body; and a method of manufacturing the porous materials for body fluid treatment for promoting the lymphocyte proliferation in lymphocyte culture.

Adsorbent for lymphocyte proliferation inhibitor and treating method

Bag for collecting cells

Vessel for culture

The present invention provides a novel material useful for selectively isolating a cell such as monocyte and the like or a protein from a body fluid and a production method thereof, a physiological material using the material and an isolation material using the physiological material, as well as a method of harvesting a cell such as monocyte and the like using the isolation material, a method of harvesting a protein and a method of preparing a dendritic cell.

Separating material and method for collecting cell or the like using the same

The present invention has its object to provide a direct hemoperfusion adsorber packed with an adsorbent made by using a water-insoluble carrier having a relatively readily available particle size distribution, with water-insoluble microparticles having been removed therefrom, without needing any special granulation apparatus or coating apparatus, and method of obtaining a direct hemoperfusion adsorbent having water-insoluble microparticles removed therefrom. Now, a direct hemoperfusion adsorber has been obtained that is packed with an adsorbent having a number average particle diameter of not smaller than 300 &#x3bc;m but not larger than 600 &#x3bc;m, with the coefficient of variance in particle diameter distribution being not lower than 10% but not higher than 20%, and having water-insoluble microparticles removed therefrom to a safe level, without the loss of the adsorbent, by using a water-insoluble microparticle-removing-mesh such that the ratio of the mesh opening size for removing water-insoluble microparticles to the mesh opening size of the adsorber is not lower than 1.3 but not higher than 1.5.

Direct hemoperfusion adsorber packed with adsorbent having water insoluble microparticle removed therefrom, and method of obtaining direct hemoperfusion adsorbent having water insoluble microparticle removed therefrom

This invention relates to a granulocyte adsorbent comprising a polymer compound having an unsubstituted hydroxyl group and a hydroxyl group in which H has been substituted with at least one substituent R, a method for producing such adsorbent, a device for adsorbing granulocytes and a system for removing granulocytes using such adsorbent, and body fluid or a cell suspension from which granulocytes have been removed using such adsorbent.

Granulocyte adsorbent

A safe and practically useful body fluid processor whereby blood taken out from a patient can be directly processed, characterized by having a favorable passage of the blood cell and showing an extremely low risk of the generation and leakage of microparticles. Namely, a body fluid processor enabling direct hemoperfusion wherein the ratio of sedimented particles to the volume of the space in which the particles for processing body fluid are to be packed is 100% or less and the space in which the particles for processing body fluid are to be packed in the body fluid processor is filled with the particles for processing body fluid and a filling liquid at a ratio of 95% or more but not more than 100%.

Body fluid processor enabling direct hemoperfusion

An apparatus for inspecting the coating of a fluorescent substance on a plasma display panel includes an illumination device for irradiating UV light onto the fluorescent substance for causing the fluorescent substance to emit light, and an imaging device for picking up the emission of the fluorescent substance. A filter, that lets only light of certain wavelengths in accordance with light emission characteristics of the fluorescent substance pass, is arranged between the imaging device and the panel being inspected.

Apparatus for inspecting a fluorescent substance on a plasma display

The present invention has its objects to provide an adsorbent capable of efficiently adsorbing and removing LDL and VLDL from various lipoprotein-containing solutions, as well as a lipoprotein adsorber in which the adsorbent is used. This invention is related to a lipoprotein adsorbent which comprises a water-insoluble carrier having, on at least one part of the surface of the carrier, at least one group (other than p-nitrobenzoic acid) selected from the group consisting of groups represented by the general formula, and groups represented by the general formula.

Lipoprotein adsorbent and lipoprotein adsorber made with the use of the same

Growing community of inventors

Takasago, Japan

Akira Kobayashi