Vertex Pharmaceuticals, Inc.

Akira Joseph Shimizu

Michael Aaron Brodney

Jingrong Cao

John E Cochran

Jon H Come

Suganthini S Nanthakumar

Haoxuan Wang

Leslie A Dakin

Timothy J Senter

Brad D Maxwell

Steven David Stone

Elena Dolgikh

Samantha Angle

Jun Myun Ahn

Jessica Howard Olsen

Hardwin O'Dowd

Hardwin O′dowd

The disclosure provides at least one entity chosen from compounds of Formula I, a tautomer thereof, a deuterated derivative of that compound or tautomer, and a pharmaceutically acceptable salt of any of the foregoing, compositions comprising the same, and methods of using the same, including uses in treating APOL1-mediated diseases, including pancreatic cancer, focal segmental glomerulosclerosis (FSGS), and/or non-diabetic kidney disease (NDKD).

Inhibitors of APOL1 and methods of using same

Growing community of inventors

Framingham, MA, United States of America

Akira Joseph Shimizu