Ss Pharmaceutical Co., Ltd.

Teikoku Seiyaku Co., Ltd.

Ssp Co. Ltd

Dojin Iyaku Kako Co., Ltd.

Akira Iwasa

Shuichi Kasai

Katsumi Imamori

Minoru Okada

Yasuo Ikeda

Hirohisa Okuyama

Toshiaki Kurazumi

Takashi Narui

Syuichi Kasai

Tetsuo Kaneko

Hideyoshi Kanbe

Toshio Yokoyama

Yutaka Murata

Hiroyuki Mizuno

Masami Moroi

Shigenori Otsuka

Toshiaki Horie

Satoru Enomoto

Takemitsu Asaoka

Toshikuni Kawaji

Ryoji Konishi

Kenji Ono

Yoichi Sawayanagi

Akihito Oji

Shuji Yamauchi

Yukihiro Saito

Misao Murata

Tetsuo Hayashi

Manabu Ishihara

Osami Makaya

Masunari Fushimi

Kimie Ominato

Tomohiko Ohsugi

Yuko Kikuchi

Teiji Murata

Noriko Aoki

Harumi Kishi

Masami Murata

Shigenori Ohtsuka

Youichi Nakajima

A preparation for oral administration which comprises S-(3-hydroxypropyl)-L-cysteine and one or more excipients, where the excipients do not cause discoloration of S-(3-hydroxypropyl)-L-cysteine is disclosled. According to an embodiment of the invention, the excipient may comprise a starch and/or a cyclodextrin. Typical starches used in the invention include corn starch, potato starch, wheat starch, and rice starch. Typical cyclodextrins used in the invention include &agr;-cyclodextrin, &bgr;-cyclodextrin, and &ggr;-cyclodextrin. Other excipients, such as saccharides, sugar alcohols and cellulose are not present in amounts that cause discoloration of the HPCY.

Oral preparations comprising S-(3-hydroxypropyl)-L-cysteine

An anti-inflammatory analgesic plaster carries thereon a base which comprises piroxicam and a polyoxyethylene nonionic surfactant having 5-15 moles of added ethylene oxide.

Anti-inflammatory analgesic plaster

A process is provided for the production of piroxicam tablets. According to the process, a solution of a water-soluble high-molecular substance is added to a mixture of piroxicam and lactose. The resultant mixture is granulated and then compressed into tablets.

Piroxicam tablets and production and process thereof

Described is a stable liquid preparation of complex vitamin for internal use. The preparation containing vitamin B.sub.1 and vitamin B.sub.12, and as a sweetening agent, a sugar alcohol. The pH of the preparation has been adjusted to 3.5 to 4.5.

Stable liquid preparation of complex vitamin for internal use

The present invention relates to a sustained-release suppository preparation characterized by comprising an acidic drug or a salt thereof which can be absorbed by rectal administration and an acidic compound or a pH buffering agent. The sustained-release suppository preparation of the present invention exhibits no rapid increase in blood concentration immediately after the administration and maintains its action for a long period of time. Thus, it is safer and exhibits a better therapeutic effect.

Sustained release suppository

Antiphlogistic-analgesic plaster comprising triacetin and piroxicam

A controlled release-initiation and controlled release-rate pharmaceutical composition in which a drug-containing composition is coated with a membrane layer comprising a water insoluble high polymer and silicone. The starting time for the release of drugs from the controlled release-initiation and controlled release-rate pharmaceutical composition of this invention and the drug-releasing rate thereafter can be controlled at will.

Controlled release-initiation and controlled release-rate pharmaceutical

An antiinflammatory and analgesic gel preparation comprising diclofenac or its salts, an ester of dibasic acid, a lower alcohol, and a nonionic polymer or a mixture of nonionic polymers selected from the group consisting of (a) 1.5-4% by weight of hydroxypropyl cellulose having a molecular weight of 500,000 or greater, (b) 2-4% by weight of hydroxyethyl cellulose having a molecular weight of 1,250,000 or greater, and (c) 1.5-4% by weight of a mixture of hydroxypropyl cellulose having a molecular weight of 500,000 or greater and hydroxyethyl cellulose having a molecular weight of 1,250,000 or greater, and having a viscosity of 5,000-35,000 cps and an yield value of 5 dyn/cm.sup.2 or greater. The gel preparation is excellent in the percutaneous absorption of diclofenac or its salts and provides good properties upon use and superior medical effects of diclofenac or its salts.

Antiinflammatory and analgesic gel preparation

A pranoprofen-containing, suspending medicinal composition is formed of the following three ingredients (a) to (c):

Pranoprofen-containing, suspending medicinal composition

Antiinflammatory gel preparation

Described herein are antidiarrheal compositions containing loperamide hydrochloride as an effective ingredient and a saccharide, for example, a monosaccharide, oligosaccharide or sugar alcohol in an amount as much as at least 3,000 times the weight of loperamide hydrochloride.

Antidiarrheal compositions containing loperamide hydrochloride and a

Compressed molded preparations are disclosed. In the preparation coated granules of a pharmaceutical composition are compressed and molded together with non-coated component(s) containing 10% or more by weight of non-swelling polymers. According to the preparation there is little breakdown of the coating of coated granules at the time of compressing and molding, and the rate of disintegration, and in turn, the release rate of the pharmaceutical component, can be freely controlled or modulated.

Compressed-molded preparations

Compositions suitable for use in the preparation of dosage-form active vitamins D.sub.3 are disclosed. Each composition comprises an active vitamin D.sub.3 and a stabilizer selected from polyvinylacetal diethylaminoacetate and hydroxypropylcellulose. Also disclosed are processes for the preparation of stable dosage-form active vitamins D.sub.3. Each process comprises adding the above stabilizer to an active vitamin D.sub.3 and then adding a pharmaceutically-acceptable carrier to the resultant mixture.

Composition for the preparation of dosage-form active vitamins D.sub.3

A sustained-release pranoprofen preparation is disclosed. The preparation comprises an effective amount of pranoprofen and one or more sustained-release components selected from the group consisting of oily components, water-soluble components, water-insoluble components, and intestinally soluble components. It controls release of pranoprofen and lowers the maximum pranoprofen concentration in blood, maintaining its concentration in blood at a certain level for a long period of time. It reduces risks of side effects and can effectively treat diseases with dosing once or twice a day.

Sustained-release pranoprofen preparation

A diclofenac sodium plaster has a backing material and a paste spread on the backing material. The paste is composed of diclofenac sodium, a penetration enhancer composed of 1-menthol and propylene glycol, and a hydrophilic base composed principally of a water-soluble polymer.

Diclofenac sodium plaster

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Yotsukaido, Japan

Akira Iwasa