University of Minnesota

Des-tyr Dynorphin Partnership

Akira E Takemori

Philip S Portoghese

Nancy M Lee

Horace H Loh

Novel peptides of the invention are dynorphin analogues and have similar activity to endogenous dynorphin, but are des-Tyr or des-Tyr-Gly with respect to endogenous dynorphin and have at least seven amino acid residues. The novel peptides have therapeutic uses, such as administration to a host tolerant to a narcotic analgesic in order to potentiate activity of the narcotic analgesic and/or to block withdrawal symptoms.

Des-Tyr dynorphin analogues

A motion provided to alleviate the tolerance to, or dependence on, an opiate analgesic, by the administration of an effective amount of a selective delta opioid receptor antagonist to a human patient in need of such treatment.

Growing community of inventors

Edina, MN, United States of America

Akira E Takemori