Wakunaga Seiyaku Kabushiki Kaisha

Wakunaga Pharmaceutical Co., Ltd.

Wakunaga Phaemaceutical Co., Ltd.

Akio Yamane

Takanori Oka

Kenichi Miyoshi

Hironari Matsunaga

Satoru Nakagami

Yusuke Wataya

Kimiko Ubukata

Takao Tanaka

Noriko Tsukumo

Tatsuro Kawasoe

Shinji Wakisaka

Kenichi Tsukumo

The present invention provides CD36 mutant gene and methods and kits for diagnosing diseases caused by a lipid metabolism abnormality.

CD36 mutant gene and methods for diagnosing diseases caused by abnormal lipid metabolism and diagnostic kits therefor

Method for suppressing nonspecific hybridization in primer extension

Primer for gene amplification, method for nucleic acid discrimination

Detection of malaria

A microtiter well in which a single stranded nucleic acid including a plurality of sequences specifically hybridizalbe with a target nucleic acid is immobilized is disclosed. The single stranded nucleic acid is derived from a phage or a phage-plasmid. The microtiter well enables a target nucleic acid to be specifically detected with a high sensitivity and high efficiency and further enables the detection procedure to be automated.

Microtiter well for detecting nucleic acid

A method and a kit for detecting methicillin-resistant Staphylococcus aureus which use, as primers in a gene amplification reaction, the four oligonucleotides represented by the following nucleotide sequences (1) through (4):

Method and kit for detecting methicillin-resistant Staphylococcus aureus

Method of nucleic acid-differentiation and assay kit for nucleic acid

An intended nucleic acid is determined in a sample by a method in which at least one of the nucleic acid strands of the intended nucleic acid is subjected to hybridization with a primer and to chain-extension reaction over the primer to form a synthesized nucleic acid which is complementary to and in hybridization with the strand; a copy of the intended nucleic acid is obtained, which copy is (a) the nucleic acid of the double-stranded double produced by the chain-extension reaction, or (b) the synthesized nucleic acid freed from the double-stranded nucleic acid, or (c) a double stranded nucleic acid form from a pair of the synthesized nucleic acids complementary with each other; and it is determined whether the copy is present in the sample thereby to know whether the intended nucleic acid is in present in the sample.

Method for detecting target nucleic acid in specimen

The present invention discloses a primer for detecting methicillin-resistant or toxic shock syndrome toxin-1 Staphylococcus spp. comprising any one of nucleotide fragments of sequences (1) to (4):

Detection for Staphylococcus spp.

A poly-labelled oligonucleotide having a plurality of labels, comprising labels carried on a polylysine and having the polylysine introduced on the extension from 5'- and/or 3'-end through phosphate group is useful as a probe for hybridization.

Poly-labelled oligonucleotide derivative

Growing community of inventors

Hiroshima, Japan

Akio Yamane