Banyu Pharmaceutical Co. Ltd

Msd K.k.

Akio Sato

Toshifumi Kimura

Hiroshi Kawamoto

Hisashi Ohta

Atsushi Satoh

Gentaroh Suzuki

Satoru Ito

Yasushi Nagatomi

Yukari Hirata

A compound represented by the formula (I): or a pharmaceutically acceptable salt thereof, wherein: This compound has a metabotropic glutamate receptor 1 inhibitory effect, and therefore is useful for the treatment of a brain disorder such as convulsion, acute pain, inflammatory pain, chronic pain, cerebral infraction or transient cerebral ischemic attack, a mental dysfunction such as schizophrenia, and a disease such as anxiety and drug addition.

1,4-substituted piperazine derivatives

The present invention provides the compounds represented by formula (I): (I) or pharmaceutical salts thereof, wherein: 

Diaryl-substituted five-membered heterocycle derivative

The present invention relates to a compound represented by the formula (I): or a pharmaceutically acceptable salt thereof, wherein: Ris a linear or branched alkoxy group, a cycloalkoxy group, a linear or branched lower alkyl group, etc.; Ris halogen atom, a lower alkyl group, etc.; Qis carbon atom or nitrogen atom; Qis carbon atom which may be substituted with oxo group; the formula (III):&#x2003;&#x2003;(II)is a single bond or a double bond; A is a group selected from the group consisting of the substitutent group &#x3b1;; and Ris hydrogen atom, a lower alkyl group, cyano group, an alkoxy group or a trialkylsilyl group; having an mGluR1 inhibiting action and being useful as treatment and/or prevention of convulsion, acute pain, cerebral disturbance such as cerebral infarction or transient cerebral ischemia onset, anxiety, chemical dependency or Parkinson's disease.

Biaryl derivatives

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Ushiku, Japan

Akio Sato