Tanabe Seiyaku Company, Limited

Akio Ohtani

Tameo Iwasaki

Masanori Inamasu

Takashi Nishitani

Hitoshi Iwasaki

Hiroshi Ohmizu

Kazuyuki Kitamura

Jun Murakami

Hiroshi Sai

Tsuyoshi Ohgiku

A novel butadiene derivative of the formula:

Butadiene derivatives and process for preparing thereof

Novel butadiene derivatives of the formula [I]: ##STR1## wherein Ring A is tri-lower alkoxyphenyl, R.sup.1 and R.sup.2 combine each other to form a group of the formula: ##STR2## or one of R.sup.1 and R.sup.2 is lower alkoxy, and the other is group of the formula: -NHR.sup.3, in which R.sup.3 is hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy, substituted or unsubstituted amino, hydroxy or pyridylcarbonyl, or salts thereof, these compounds have excellent antithrombotic activity and are useful as antithrombotic drug, or synthetic intermediate for preparing other antithrombotic drug.

Butadiene derivatives and process for using the same

Novel succinimide derivatives of formula I!: ##STR1## wherein Ring A is tri-lower alkoxyphenyl, R.sup.1 and R.sup.2 combine each other to form a group of the formula:

Succinimide derivatives and process for preparing the same

There are disclosed a prophylactic and curing composition for arteriosclerosis, comprising as an active ingredient an 8-chloro-1,5-benzothiazepine derivative represented by the formula: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 each represent lower alkyl groups, or a pharmaceutically acceptable salt thereof, and a method of treatment of arteriosclerosis.

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Kawaguchi, Japan

Akio Ohtani