Hokkaido University

Mochida Pharmaceutical Co., Ltd.

Akio Minami

Norimasa Iwasaki

Nobuo Ohzawa

Mariko Imai

Yasuhiko Kasahara

Tatsuya Igarashi

Daisuke Kawamura

Chihiro Miyajima

Fumiyoshi Kasahara

Atsushi Sukegawa

Daisuka Kawamura

A novel composition for regenerating a cartilage has been demanded, which can achieve a good effect of regenerating a hyaline cartilage that is a nearly normal cartilage without requiring the use of any transplanted cell. The present invention provides a composition for regenerating a cartilage, wherein (a) a monovalent metal salt of low endotoxin alginic acid and (b) SDF-1 are used in combination.

Method for regenerating cartilage comprising applying a monovalent metal salt of alginic acid and SDF-1

The present invention provides a composition for regenerating cartilage or treating a cartilage disease containing a monovalent metal salt of alginic acid for which the endotoxin level thereof has been lowered to an extent that does not substantially induce inflammation or fever. As a result, it is possible to provide a composition for regenerating cartilage that improves cartilage regenerative action and ease of application to a cartilage injury lesion, and a composition for treating a cartilage disease, which has the effects of protecting cartilage from mechanical irritation, inhibiting degenerative changes in cartilage caused by wear and inflammation, repairing a cartilage injury lesion, and inhibiting inflammation and pain of joint tissue.

Method for regenerating hyaline cartilage

Compositions and methods for treating cartilage disease

The present invention provides compositions and methods for treating a joint disease containing as an active ingredient thereof a monovalent metal salt of alginic acid for which the endotoxin level thereof has been lowered to an extent that does not substantially induce inflammation or fever. As a result, it is possible to provide a composition for treating a joint disease which has the effects of protecting cartilage from mechanical irritation, inhibiting degenerative changes in cartilage caused by wear and inflammation, repairing cartilage injuries, suppressing inflammation and pain of joint tissue, inhibiting degeneration of synovial tissue, and inhibiting osteochondral destruction.

Composition for treating arthritic disorder

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Hokkaido, Japan

Akio Minami