Fujisawa Pharmaceutical Company, Ltd.

Astellas Pharma Gmbh

Akio Kuroda

Hirokazu Tanaka

Teruo Kyoto Oku

Hiroyuki Setoi

Kozo Sawada

Hiroshi Kayakiri

Satoshi Okada

Yuki Sawada

Shigeki Satoh

Takayuki Inoue

Shinya Watanabe

Masashi Hashimoto

Hiroshi Marusawa

Hideo Hirai

Yuki Saitoh

Masakazu Kobayashi

Natsuko Kayakiri

Takehiko Ohkawa

Tsuyoshi Mizutani

Kazuhiko Ohne

Ichiro Shima

Toshio Kurosaki

Kouichi Tamura

Akira Nagashima

Yoshimitsu Nakajima

Aiko Wada

Naomi Hosogai

Atsushi Nomoto

Keizo Sogabe

Takayuji Inoue

A compound of the formula (I) or a pharmaceutically acceptable salt thereof: [wherein

2-cyanopyrrolidinecarboxamide compound

Anthranilic acid derivatives as inhibitors of the cGMP-phosphodiesterase

Indole derivatives as cGMP-PDE inhibitors

Process for the preparation of indolizine derivatives

Indole derivatives useful as testosterone 5.alpha.-reductase inhibitors

This invention related to compounds of the formula ##STR1## wherein the radicals are as defined in the claims. The compounds are angiotensin II antagonists useful in treating hypertension, etc.

Angiotenin II antagonizing heterocyclic compounds

This invention relates to heterocyclic derivatives useful for treating or preventing testosteron 5.alpha.-reductase mediated diseases such as alopecia, ache, prostatism and the like, which can be represented by the following formula: ##STR1## to a process for their production, to a pharmaceutical composition containing the same and to uses thereof.

Heterocyclic derivatives

The invention relates to compounds of the formula ##STR1## wherein ##STR2## represents a condensed or uncondensed imidazolyl ring and the rest of the variables are as defined in the specification. They are angiotensin II antagonists useful for treating hypertension, etc..

Angiotenin II antagonizing heterocyclic derivatives

The invention concerns compounds of the formula ##STR1## represents a condensed or uncondensed imidazolyl ring and the rest of the variables are defined in the specification. They are angiotensin II antagonists useful for treating hypertension, etc.

Angiotensin II antagonizing heterocyclic derivatives

The invention relates to treatment of diseases caused by thromboxane A.sub.2 comprising administering a compound ##STR1## wherein R.sup.1 is hydrogen or lower alkyl,

Oxygen-containing heterocyclic compound

The invention relates to novel compounds of the formula: ##STR1## wherein R.sup.1 is hydrogen, lower alkoxycarbonyl, phenylsulfonyl, phenylsulfonyl substituted with 1 to 3 substituent(s) selected from the group consisting of halogen, nitro, lower alkoxy, mono (or di or tri)halo(lower)alkyl and lower alkyl, phenylcarbamoyl, lower alkylsulfonyl, benzoyl or thienylsulfonyl; R.sup.2 is phenylsulfonyl or phenylsulfonyl substituted with 1 to 3 substituent(s) selected from the group consisting of halogen, lower alkyl, lower alkoxy and mono(or di or tri)halo(lower)alkyl, R.sup.3 is carboxy(lower)alkyl, lower alkyl substituted with carboxy and 1 to 3 halogen atom(s), esterified carboxy(lower)alkyl, carbamoyl(lower)alkyl, lower alkylsulfonylcarbamoyl(lower)alkyl, phenylsulfonylcarbamoyl(lower)alkyl, carboxyphenyl, esterified carboxyphenyl, carboxy, esterified carboxy, hydroxy(lower)alkyl, sulfino(lower)alkyl, phosphono(lower)alkyl, di(lower)alkoxyphosphoryl(lower)alkyl or halo(lower)alkyl, R.sup.7 is hydrogen or lower alkyl, and A is ##STR2## in which R.sup.8 is hydrogen or lower alkyl, or a pharmaceutically acceptable salt thereof, useful as therapeutic agents for thrombosis, asthma and nephritis.

Pyrrolidine derivatives as antiasthmatics

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Tsukuba, Japan

Akio Kuroda