Daiichi Pharmaceutical Co., Ltd.

Other

Nof Corporation

Akio Kishida

Mitsuru Akashi

Hiroshi Kikuchi

Akio Hayashi

Tetsushi Taguchi

Shinji Sakuma

A hydroxyapatite consisting substantially of Ca (PO ) (OH) , and having a crystal structure which has at least two diffraction peaks at 31-32 degrees and 26 degrees in X-ray diffractometry; and a process for producing a hydroxyapatite which comprises the step (A) of immersing a substrate in a first aqueous solution containing calcium ions and a second solution containing PO ions to generate the hydroxyapatite at least on the surface of the substrate and the step (B) of recovering the hydroxyapatite from the substrate.

Hydroxyapatite, composite, processes for producing these, and use of these

A method for preparing a hydroxyapatite composite is disclosed. This method comprises alternately soaking a matrix which has been made hydrophilic at least on its surface, in a calcium ion aqueous solution containing calcium ions and substantially free of phosphate ions and in a phosphate ion aqueous solution containing phosphate ions and substantially free of calcium ions to securely form hydroxyapatite at least on the surface of the matrix. Also disclosed is a biocompatible material composed of the hydroxyapatite composite obtained by the method.

Method for preparing hydroxyapatite composite and biocompatible material

The present invention is directed to particulate carriers useful as drug carriers in a drug delivery system (DDS) and to pharmaceutical compositions making use of such carriers. The invention is characterized by the use, as the particulate carrier, of: graft copolymer (A) whose graft chain is poly N-alkylacrylamide chain, poly N-alkylmethacrylamide chain, etc.; and a composition containing a combination of the graft copolymer (A) and at least one graft copolymers selected from the group consisting of graft copolymers (B-1) having polyacrylic acid or polymethacrylic acid as the graft chain and graft copolymers (B-2) having a polyvinyl amine compound as the graft chain.

Fine grain carriers and medicinal composition prepared with the use of the same

Fine grain carriers and medicinal composition prepared with the use of

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Kagoshima, Japan

Akio Kishida