Nipro Corporation

Tokyo Medical and Dental University

Japan As Represented by President of National Cardiovascular Center

Adeka Corporation

National Cerebral and Cardiovascular Center

The Chemo-sero-therapeutic Research Institute

Sapporo Medical University

Shimane University

Ibaraki University

Tokyo Iken Co., Ltd.

Miwatec Co., Ltd.

Japan As Represented by the President of National Cardiovascular Center

Km Biologics Co., Ltd.

Akio Kishida

Toshiya Fujisato

Tsutomu Furuzono

Toru Masuzawa

Tetsuya Higami

Soichiro Kitamura

Seiichi Funamoto

Tsuyoshi Kimura

Takanori Uchida

Takeshi Nakatani

Jun Negishi

Kozo Miyazaki

Ken-ichiro Hiwatari

Hisatoshi Kobayashi

Noriko Shinya

Takao Hanawa

Yusuke Tsutsumi

Akiko Tasaki

Haruki Obara

Shoko Tokorozaki

Hideki Saga

Takao Ema

Souichiro Kuwa

Yoshihide Hashimoto

Takuro Kogoshi

Yusuke Suga

Kuniharu Kobayashi

Chiaki Yoshikawa

Satomi Harano

Sumika Miyabashira

Junichi Matsuda

Ken-Ichiro Hiwatari

Kwangwoo Nam

An anti-adhesion material comprising decellularized tissues and a biocompatible polymer or fibrin glue; a method for preparing an anti-adhesion material comprising complexing a biocompatible polymer or fibrin glue to decellularized tissues; an anti-adhesion material kit comprising decellularized tissues and a biocompatible polymer or fibrin glue; a substitute biomembrane comprising decellularized tissues and a biocompatible polymer or fibrin glue; a method for preparing a substitute biomembrane comprising complexing a biocompatible polymer or fibrin glue to decellularized tissues; and a substitute biomembrane kit comprising decellularized tissues and a biocompatible polymer or fibrin glue.

Anti-adhesion material and substitute biomembrane using decellularized tissue

Provided are: a method for preparing a decellularized tissue product in which decellularized tissue can be filled with liquid while changes in the structure of support tissue constituting the decellularized tissue are inhibited; and a graft provided with a decellularized tissue product. The method for preparing a decellularized tissue product includes a reduced-pressure step for bringing an animal-derived decellularized tissue material and a liquid into contact under reduced-pressure conditions, and/or a pressurized step for bringing same into contact under pressurized conditions. The graft is provided with a decellularized tissue product prepared by the method of preparation.

Method for preparing decellularized tissue product, and graft provided with decellularized tissue product

An artificial blood vessel that can be transplanted to blood vessels with a small diameter, can be adjusted to an arbitrary size of a diameter, improves in invasiveness when a graft is taken, and overcomes the problem on the provision of a graft is provided. An artificial blood vessel prepared from a decellularized tubular structure, which is prepared by processing a decellularized, sheet-like blood vessel (decellularized blood vessel sheet) into a roll structure, and a tissue adhesive, wherein a portion which is contacted with blood that flows within the artificial blood vessel consists of the tissue of the tunica intima lined with the tissue of the tunica media whereas a portion of the sheet that overlaps when the sheet is processed into a roll structure (overlap width) consists of the tissue of the tunica media and wherein a tissue adhesive is applied to the overlap width.

Artificial blood vessel using decellularized blood vessel sheet

It is intended to provide a method of preparing a decellularized soft tissue whereby swelling after an ultrahigh pressure treatment can be inhibited, etc. The above-described method of preparing a decellularized soft tissue comprises the application step wherein an ultrahigh hydrostatic pressure is applied to an isolated soft tissue in a medium to thereby disrupt cells in the soft tissue, and the removal step wherein the disrupted cells are removed. As the medium, use is made of an aqueous solution containing a water-soluble polysaccharide such as dextran.

Method of preparing decellularized soft tissue, graft and culture material

Methods and apparatus for controlling biological functions with mechanical vibration are provided. Stimulation is applied to cells of one of an organism, bacteria or virus by mechanical vibration. The biological function comprises biological functions relating to cell growth. The biological functions relating to cell growth may include at least one of cell cultivation, cell proliferation, cell fusion, and cell differentiation.

Method for controlling biological function with mechanical vibration and device therefor

A method of injecting cells into a biological tissue comprising thrusting injection needle () under microvibration into tissue () secured by suction to tissue suction means () and effecting injection of a cell suspension into the tissue through the needle. There is also provided an apparatus for cell injection into the biological tissue.

Method of cell injection into biotissue and apparatus therefor

A devicefor bonding adherends Tand T, as a device for bonding biological tissue to biological tissue or a biological tissue bonding material, comprises: a clamping partfor clamping the adherends Tand Tbetween membersand; a pressing partfor pressing the membertowards the member; a pressure control partfor controlling the pressure by the pressing part; a heating elementbuilt into the member; a heating control partfor controlling the heating by the heating element; a vibration generating partfor generating microvibration; and a vibration control partfor controlling the microvibration generated by the vibration generating part

Biological tissue bonding device and biological tissue bonding medical instrument

An apparatus and method for inoculating a biological substrate with cells include provision for rotating a container in which the substrate and a cell suspension are received about first and second axes of rotation. The apparatus comprises said container, first drive means for rotatably supporting the container about the first axis, and second drive means for rotatably supporting the first drive means about the second axis. The first and second axes of rotation do not lie in the same plane and extend in different directions so that the container revolves around the second axis while the container is rotating about the first axis. The inoculation method utilizes this apparatus.

Device and method for uniformly inoculating a substrate having three-dimensional surfaces

A method of efficiently removing or fixing donor cells from a native tissue of mammalian origin comprises immersing the tissue in a treating solution, and irradiating the tissue with microwave while maintaining the temperature thereof in the range between 0&#xb0; C. and 40&#xb0; C.

Method of treating biological tissue by microwave-irradiation

A reactive functional group is introduced into titanium oxide, and an active group which is capable of reacting with the reactive functional group is introduced into a polymer-based material, and the reactive functional group and the active group are reacted with each other, thereby producing a titanium oxide complex in which the polymer-based material and the titanium oxide chemically bond to each other. Further, a functional group of the polymer-based material and the titanium oxide are reacted with each other, thereby producing the titanium oxide complex without performing chemical pretreatment with respect to the titanium oxide.

Titanium oxide complex and production method thereof, and medical material using the same

Growing community of inventors

Tokyo, Japan

Akio Kishida