Ono Pharmaceutical Co., Ltd.

Doggyman H. A. Co., Ltd.

Medarex Inc.

Akio Hayashi

Nobuyuki Hamanaka

Hideaki Tada

Masayoshi Matsuo

Makoto Hiramatsu

Shiro Shibayama

Shinji Nakade

Takao Yoshida

Tomoya Sumitsuji

Seishi Katsumata

Hidehiro Suzuki

Shin Fukudo

Chie Murata

Tamon Hayashi

Jun Murai

Tomoyuki Bando

To provide a biomarker which is a metabolite included in a biological sample, and which can be collected in a noninvasive method and detected in a convenient analysis method, and which varies according to progression of pathological conditions of irritable bowel syndrome (IBS). Furthermore, such biomarkers are useful for determination of the presence or absence of morbidity of IBS, determination of severity of IBS, determination of types of IBS, determination of necessity of treatment of IBS, and confirmation of drug efficacy of an IBS therapeutic agent.

Biomarker for diagnosis of irritable bowel syndrome

Provided is a massaging tool for pets usable for pets of various sizes and various portions of pets, and having excellent maintenance property. A massaging tool for pets, which comprises two approximately cylindrical roller bodies, and a grip body having a branched supporting part which has a first and second supporting parts in the form of right and left pair, and can vary separation distance therebetween, wherein each of the first and the second supporting part supports the roller body in the freely rotatable manner so that a rotation axis of the roller body is oriented in the direction approximately vertical to the direction of the separation distance.

Massaging tool for pets

An exercise equipment exercise equipment that can readily switch arrangement of a person exercise apparatus and a dog exercise apparatus between the state where a person and a dog run facing each other and/or the state where the person and the dog run side by side. The person exercise apparatus includes a frame, a crank mechanism having a crank shaft rotatably supported by the frame, a crank coupled to the crank shaft, and a pedal rotatably supported by the crank, and a joint rotatingly driven by the crank mechanism. An annular travelling belt travels with a dog, a roller drives the travelling belt, and a transmission mechanism transmits rotational motion of the joint to the roller An input shaft is aligned with a rotary shaft of the joint with respect to a mounting face of the exercise equipment. A coupling mechanisms is detachably engageable with the joint at each end.

Exercise equipment

A purpose of the present invention is to provide a method capable of more effectively prescribing an anti-human PD-1 antibody for anti-cancer therapy, a method for estimating or optimizing therapeutic efficacy thereof, and further an efficacy marker that can be used in methods thereof. The present invention enables selection of the cancer patient in whom the therapeutic efficacy of the anti-human PD-1 antibody can be expected in future, by measuring the change which is more than a certain level of several kinds of efficacy markers in blood, after administering the initial dose or doses of the anti-human PD-1 antibody compared to that prior to administering the initial dose, and provides a new prescription of the anti-human PD-1 antibody for anti-cancer therapy.

Use of an efficacy marker for optimizing therapeutic efficacy of an anti-human PD-1 antibody on cancers

The present invention relates to a method for screening a medicine using a protein, and a compound obtained by the screening method. A compound or a salt thereof inhibiting activity or expression of the protein of the present invention, a neutralizing antibody against the protein, a polynucleotide that are complementary to a polynucleotide coding the protein, and the like can be used as an agent for preventing and/or treating neurodegenerative diseases and the like. Moreover, a compound or a salt thereof enhancing activity or expression of the protein of the present invention, the protein or a partial peptide thereof, a polynucleotide coding the protein, and the like can be used as an agent for preventing and/or treating cancers and the like. Furthermore, the protein of the present invention is useful as a reagent for screening a compound inhibiting or enhancing activity of the protein.

Soluble ENPP4 protein

To provide a highly active LPA and a method of screening therewith. There is provided a method of screening a preventive and/or therapeutic substance for diseases in which LPA takes part, characterized in that a compound represented by any of formula (I), (II) and (III): [wherein the meaning of characters are described in the description] is used. The compounds obtained by the screening method or the screening kit of the present invention, their salts, their solvates and prodrugs thereof would modulate the binding of highly active LPA with LPA receptor in human and other mammals, so that they can be used as a preventive and/or therapeutic agent for diseases in which LPA takes part, for example, urinary diseases, central nervous diseases, inflammatory diseases, circulatory diseases, cancer, diabetes, immune system disorders and alimentary diseases.

Highly active lysophosphatidic acid and method of screening therewith

Peptides, method for assaying human pepsinogen II or human pepsin II, and assaying kit

Peptides, methods for assaying human pepsinogen I or human pepsin I and assay kits

Polyclonal and monoclonal antibodies are obtained specific to mevalonic acid, having low cross-reactivity with mevalonic acid analogues, such as glutaric acid, 3-methylglutaric acid and 3-hydroxy-3-methylglutaric acid. The antibodies may be used for determination of mevalonic acid providing an immunoassay excellent in sensitivity, specificity and reproducibility.

Antibodies for mevalonic acid and methods for immunological

Growing community of inventors

Osaka, Japan

Akio Hayashi