Daiichi Pharmaceutical Co., Ltd.

Kabushiki Kaisha Yakult Honsha

Daiichi Seiyaku Co., Ltd.

Other

Akio Ejima

Satoru Ohsuki

Hirofumi Terasawa

Kouichi Uoto

Hiroaki Tagawa

Hiroyuki Naito

Hitoshi Ohki

Masamichi Sugimori

Minoru Furukawa

Takeshi Hayano

Ikuo Mitsui

Chie Makino

This invention provides compounds having antitumor effect, namely a compound represented by the following formula (I) or (Ia) having various substituents in which G and G are condensed tricyclic heterocyclic rings or salts thereof, and a compound represented by the following formula (Ib) having various substituents or salts thereof.

Pyrazole derivatives and salts thereof

Pyrazole derivatives

Hexa-cyclic compound

The present invention relates to cis- and trans-forms of pyrazole derivatives, salts thereof, or agents containing the same, and represented by the general formula (I):

Pyrimidinylpyrazole derivatives

A novel hexa-cyclic compound, a derivative of camptothecin, of the general formula: ##STR1## The compound is prepared from an aminoketone compound and a pyranoindolizine compound by the condensation-ring closing reaction. It is abundantly water-soluble, and has an excellent antitumour activity and a high degree of safety, and can be applied as an antitumour medicine for curing tumors of various kinds.

A novel hexa-cyclic compound, a derivative of camptothecin, of the general formula: ##STR1## The compound is prepared from an aminoketone compound and a pyranoindolizine compound by the condensation-ring closing reaction. It is abundantly water-soluble, and has an excellent antitumor activity and a high degree of safety, and can be applied as an antitumor medicine for curing tumors of various kinds.

Method for treating leukemia with a hexa-cyclic compound

Substituted 1H,12H-benz-[DE]pyrano[3',4':6,7]

A novel hexa-cyclic compound, a derivative of camptothecin, of the general formura: ##STR1## The compound is prepared from an aminoketone compound and a pyranoindolizine compound through Friedlaender reaction. It has an excellent antitumour activity and a high degree of safety, and can be applied as an antitumour medicine for curing tumors of various kinds.

A novel hexa-cyclic compound, a derivative of camptothecin, of the general formula: ##STR1## The compound is prepared from an aminoketone compound and a pyranoindolizine compound through Friedlaender reaction. It has an excellent antitumor activity and a high degree of safety, and can be applied as an antitumor medicine for curing tumors of various kinds.

Hexa-cyclic camptothecin derivatives

Novel cephalosporin derivatives and salts thereof are disclosed. These compounds exhibit excellent antimicrobial activity against a wide variety of Gram-negative and Gram-positive bacteria and also have other excellent characteristics as a medicine such as stability and low toxicity. These compounds can be administered in a form of subcutaneous, intravenous or intramuscular injections.

Cephalosporin derivatives and salts thereof

A pyranoindolizine derivative represented by the following general formula (I): ##STR1## wherein R means a hydrogen atom or hydroxyl group and Q denotes &gt;C.dbd.O or ##STR2## with a proviso that Q is other than &gt;C.dbd.O when R is a hydrogen atom. Its preparation process is also described.

Growing community of inventors

Tokyo, Japan

Akio Ejima