Japan Science and Technology Agency

Kagoshima University

Toagosei Company, Ltd.

National University Corporation Kagoshima University

Akio Arano

Yasuo Suda

Michael Sobel

Hiroshi Suzuki

Akinori Kitamura

Shoichi Kusumoto

Masahiro Wakao

Toshihisa Shimano

Hideki Hayashi

The present invention provides a novel linker compound which minimizes any nonspecific hydrophobic interactions and is capable of easily adjusting the length to a disulfide group subjected to metal bond to thereby enable effective formation of a metal-sulfur bond; novel ligand conjugate and ligand carrier, and a process for producing them. The linker compound is of a structure represented by the following general formula (1) where a, b, d, e are independently an integer of 0 to 6. X has a structure serving as a multi-branched structure moiety including three or more hydrocarbon derivative chains, wherein the hydrocarbon derivative chains each include an aromatic amino group at an end thereof, and may or may not include a carbon-nitrogen bond in a main chain thereof. The ligand conjugate includes the linker compound having a sugar molecule introduced therein.

Linker compound, ligand conjugate, and production methods thereof

The objective of the present invention is to provide a polycarbosilane having excellent solubility in common organic solvents and a method for production thereof. The polycarbosilane of the present invention is a polymer which is represented by the following general formula (1) and has an oxetanyl group in a side chain. Ris an alkyl group having no oxetanyl groups, aryl group having no oxetanyl groups, or an organic group having an oxetanyl group, Ris an organic group having an oxetanyl group, Ris an alkylene group, an arylene group, or an aralkylene group, and n is an integer of 5 to 200. 

Polycarbosilane and method for producing same

A linker compound has a structure represented by general formula (1) below, where n is an integer of 1 to 6, and X has a structure serving as a multi-branched structure moiety including three or four hydrocarbon derivative chains each having an aromatic amino group at an end and a carbon-nitrogen bond in a backbone. A ligand includes the linker compound and a sugar introduced into the linker compound 

Linker compound, ligand, and producing method thereof

A versatile linker compound has a structure represented by following general formula (1), wherein Y has a structure represented by O or NH, and X has a structure serving as a multi-branched moiety including four hydrocarbon derivative chains each of which has an aromatic amino group at an end thereof, and may or may not have a carbon-nitrogen bond in a backbone thereof. With the versatile linker compound, sugar molecules can be two-dimensionally arranged on a surface of a protein-analyzing supporter with high reproducibility. Also, a ligand includes the versatile linker compound and a sugar molecule introduced thereinto.

Versatile linker compound, ligand, and producing method thereof

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Nagoya, Japan

Akio Arano