Nippon Oil Fats Co., Ltd.

Nof Corporation

Hoeschst Aktiengesellschaft

Akinori Suginaka

Tsuyoshi Miyazaki

Tohru Yasukohchi

Masahiko Fujii

Kouzoh Sanchika

Shigeru Kitano

Shinichi Akimoto

Yoshihito Kadoma

Mitsuo Mizuno

Mitsuhiro Nishida

Yoshishige Murata

Takeo Matsumoto

Shin-ichi Akimoto

Mikio Akita

Yoshiyuki Koyama

Shuji Kojima

Shoichi Shutoh

Motoharu Iwatsuru

Kazuo Maruyama

A reactive vesicle comprising, as a vesicle-forming component, a reactive phospholipid derivative represented by the following general formula (1) and a functional substance-fixed vesicle prepared by reacting the reactive vesicle with a functional substance: ##STR1## in which R.sup.1 C(.dbd.O) and R.sup.2 C(.dbd.O) each represent an aliphatic acyl group, R.sup.3 denotes hydrogen atom or methyl group, OA represents an oxyalkylene group of 2-4 carbon atoms, n indicates the average number of moles of added oxyalkylene group and is 1-1,000, p is 0 or 1, X represents ##STR2## with q and r each being an integer of 0 to 4 or 1 to 4, respectively, and M denotes hydrogen atom or an alkli metal atom.

Reactive vesicle and functional substance-fixed vesicle

A novel and useful phospholipid derivative to be used for a reactive vesicle-forming agent, which is represented by the following general formula (1): ##STR1## in which R.sup.1 C(.dbd.O) and R.sup.2 C(.dbd.O) represent each an aliphatic acyl group, R.sup.3 denotes hydrogen atom or methyl group, OA represents an oxyalkylene group of 2-4 carbon atoms, n indicates the average addition mole number of added oxyalkylene group and is 1-1,000, p is 0 or 1, X represents ##STR2## with q and r being each an integer of 0 to 4 or 1 to 4, respectively, and M denotes hydrogen atom or an alkali metal atom.

Phospholipid derivative and reactive vesicle-forming agent

Method for assaying immunologically active substance and reagent therefor

The present invention provides a polymer-combined drug having directional characteristics to digestive organs, wherein it comprises a medicine combined with a polymer which has an alkyleneoxy group as a repeating unit. The polymer-combined drug is produced by reacting a polyoxyalkylene glycol having one or more terminal functional groups and a medicine, if necessary in a solvent, and if necessary in the presence of a catalyst. It is able to administer the drug orally or by intravenous injection so as to maintain the concentration in blood stably for a long time, and to absorb or take in digestive organs such as the stomach and intestines directly.

Polymer-drug conjugate and a method of producing it

It is proposed a hair-rinse liquid having pearly luster, which includes the following four components A to D, namely:

Hair-rinse liquid with pearly luster

A suppository base composition comprising 5-80% by weight of polyethylene glycol, 5-80% by weight of triglyceride of fatty acid having 6-22 carbon atoms and 5-80% by weight of a specifically limited alkylene oxide derivative has a melting point of 30.degree.-60.degree. C., a compatibility with both of a polar drug component and a non-polar drug component, and can provide suppositories having excellent moldability and storage stability.

Suppository base composition

Molded, storage stable suppository base composition of specified amounts

Growing community of inventors

Chigasaki, Japan

Akinori Suginaka