Shimadzu Corporation

National Center for Geriatrics and Gerontology

Akinori Nakamura

Naoki Kaneko

Provided are a biomarker for evaluating a cerebral A&#x3b2; accumulation state using amyloid precursor protein (APP)-derived A&#x3b2; and A&#x3b2;-like peptides in a living body-derived sample as an index, and a method for analysis thereof. A marker for determining a cerebral A&#x3b2; accumulation state, the marker comprising a combination of at least two ratios selected from the group consisting of: a ratio of A&#x3b2;1-39 (SEQ ID NO.: 1) level to A&#x3b2;1-42 (SEQ ID NO.: 3) level: A&#x3b2;1-39/A&#x3b2;1-42; a ratio of A&#x3b2;1-40 (SEQ ID NO.: 2) level to A&#x3b2;1-42 (SEQ ID NO.: 3) level: A&#x3b2;1-40/A&#x3b2;1-42; and a ratio of APP669-711 (SEQ ID NO.: 4) level to A&#x3b2;1-42 (SEQ ID NO.: 3) level: APP669-711/A&#x3b2;1-42, in a living body-derived sample.

Growing community of inventors

Obu, Japan

Akinori Nakamura