Meiji Seika Pharma Co., Ltd.

Nippon Kayaku Co., Ltd

Akinori Morikawa

Nozomu Nakanishi

Kazumi Yamamoto

Nobuto Minowa

Shizuo Shimano

Hiroki Hotta

Takashi Watanabe

Yasuhito Kato

Hirokazu Kuroda

Kenichi Yamamoto

Kouki Tanigakiuchi

Mikio Sekiguchi

[Problem] The present invention provides a method for producing and isolating a target quinolone derivative using general industrial facilities with high purity. [Solving means] The present invention also provides a method for producing a quinolone derivative, the method including reacting a ketone with an anthranilic acid derivative using an aluminum halide and removing the aluminum halide under basic conditions.

Method for producing quinolin-4(1H)-one derivative

An objective of the present invention is to provide a process for producing 4-carbonyl oxyquinoline derivatives useful as agricultural and horticultural pesticides and fungicides. The objective can be attained by a process for producing 4-carbonyl oxyquinoline derivatives represented by general formula (1), the process including reacting a quinolone derivative with a halogenated compound or an acid anhydride in the presence of a phase transfer catalyst and a base. 

Process for producing 4-carbonyloxyquinoline derivatives

An objective of the present invention is to provide a crystal of 2-ethyl-3,7-dimethyl-6-(4-(trifluoromethoxy)phenoxy)quinoline-4-yl methyl carbonate having stable physicochemical properties. The objective is attained by a crystal of 2-ethyl-3,7-dimethyl-6-(4-(trifluoromethoxy)phenoxy)quinoline-4-yl methyl carbonate that exhibits a diffraction peak pattern shown in FIG.as determined by powder X-ray diffractometry.

Stabilized crystal of 2-ethyl-3,7-dimethyl-6-(4-(trifluoromethoxy)phenoxy)quinoline-4-yl methyl carbonate, process for producing the crystal, and agricultural chemical composition comprising the crystal

Disclosed is a process for producing 6-aryloxyquinoline derivatives useful as insecticides or fungicides for agricultural and horticultural use. The process comprises a cyclization reaction step of reacting an anthranilic acid derivative represented by general formula (1) with a kenone in the presence of an acid to obtain a quinolone derivative and a condensation reaction step of reacting the quinolone derivative with a halogen compound or an acid anhydride to obtain a quinoline derivative. 

Process for producing 6-aryloxyquinoline derivative and intermediate therefor

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Kamisu, Japan

Akinori Morikawa