Mitsubishi Denki Kabushiki Kaisha

Japan Science and Technology Agency

Akinobu Suzuki

Katsuhiko Mikoshiba

Takeshi Nakamura

Yuji Sakazaki

Akiko Terauchi

Jun-ichi Goto

Etsuko Ebisui

Shoichiro Ozaki

Hideki Watanabe

Shinichi Takagi

Tsuyoshi Inoue

Hiroshi Suda

Kozo Hamada

Shouichirou Ozaki

Nobuyuki Nukina

Kouzo Hamada

Kyoko Nakamura, Legal Representative

Aiko Nakamura, Legal Representative

Hirofumi Nemoto

The present invention relates to: a ketone compound having transglutaminase-inhibiting activity, which is represented by the following Formula 1, 2, or 3: wherein Ris a substituted or unsubstituted aryl or heterocyclyl group, R, R, and Rare hydrogen atoms, n is 2, X is halogen, Rand Rindependently represent a hydrogen atom or a substituted or unsubstituted C1-C10 alkyl, aryl, or aralkyl group, wherein Rand Rare not hydrogen atoms at the same time, or Rand Rmay be taken together to form a saturated or unsaturated and substituted or unsubstituted heterocyclyl group containing a nitrogen atom (N); an inhibitor of protein crosslinking comprising the compound; and a composition for preventing or treating a protein-crosslinking causative disease, which comprises the compound or the protein crosslinking inhibitor.

Inhibitor of protein crosslinking and use of the same

The present invention provides a protein cross-linking inhibitor containing a compound represented by any of the following formulas (1)-(13), or a pharmaceutically acceptable salt thereof:R&#x2014;[&#x2014;X&#x2014;B(ZR)&#x2014;Y&#x2014;B(ZR)&#x2014;W&#x2014;]&#x2014;R,&#x2003;&#x2003;(1)R&#x2014;[&#x2014;X&#x2014;B(ZR)&#x2014;Y&#x2014;]&#x2014;R,&#x2003;&#x2003;(2)R&#x2014;[&#x2014;B(ZR)&#x2014;Y&#x2014;B(ZR)&#x2014;W&#x2014;]&#x2014;R,&#x2003;&#x2003;(3)R&#x2014;[&#x2014;X&#x2014;B(ZR)&#x2014;]&#x2014;R,&#x2003;&#x2003;(4)R&#x2014;[&#x2014;B(ZR)&#x2014;W&#x2014;]&#x2014;R,&#x2003;&#x2003;(5)R&#x2014;X&#x2014;B(ZR)-T[B(ZR)&#x2014;W&#x2014;R],&#x2003;&#x2003;(6)R&#x2014;B(OH),&#x2003;&#x2003;(7)R&#x2014;B(ZR)&#x2014;X&#x2014;B(ZR)&#x2014;R,&#x2003;&#x2003;(8)R&#x2014;B(R)&#x2014;O&#x2014;B(R)&#x2014;R,&#x2003;&#x2003;(9)R&#x2014;[&#x2014;X&#x2014;B(ZR)&#x2014;Y&#x2014;B(ZR)&#x2014;]&#x2014;R,&#x2003;&#x2003;(10)R&#x2014;[&#x2014;X&#x2014;B(ZR)&#x2014;Y&#x2014;B(ZR)&#x2014;W-Q-]&#x2014;R,&#x2003;&#x2003;(11)R&#x2014;[&#x2014;P&#x2014;X&#x2014;B(ZR)&#x2014;Y&#x2014;B(ZR)&#x2014;W&#x2014;]&#x2014;R,&#x2003;&#x2003;(12)[R&#x2014;X&#x2014;B(ZR)&#x2014;Y]B(ZR),&#x2003;&#x2003;(13)wherein each symbol is as defined in the DESCRIPTION.

Protein cross-linking inhibitor

A bisboron compound represented by the general formula (I): wherein B represents a boron atom, Y represents an oxygen or sulfur atom, Rand Rindependently represent a monocyclic aromatic group, a polycyclic aromatic group, or a heterocyclic group containing at least one heteroatom selected from oxygen, nitrogen and sulfur atoms, Rrepresents a hydrogen atom; &#x2014;(CH)&#x2014;NRR; &#x2014;CO&#x2014;(CH)&#x2014;NRR; &#x2014;COCH(NH)R; &#x2014;CHRR; &#x2014;CHCH(NH)&#x2014;R; quinolyl substituted with C1-C4 alkyl group; or C1-C4 alkyl substituted with pyridyl, piperidino or pyrrolidinyl group, and X represents a monocyclic aromatic group, a polycyclic aromatic group or a heterocyclic group, which may be the same as or different from Rand R, or a bifunctional group having a monocyclic aromatic group, polycyclic aromatic group or heterocyclic group bonded to each side of a group selected from the group consisting of a single bond, O, CH, S, SO, CHOCH, OCH, OCHCHOCH, OCHOCHCHand CHOCHCH, or a salt thereof, and a composition for controlling the intracellular calcium concentration, which comprises the compound or salt thereof as an active ingredient.

Bisboron compound

Electronic devices are provided with a high-frequency circuit board and a coaxial connector connected to external high-frequency signals to the circuit board. The lead terminal of the coaxial connector is directly soldered to a land on the circuit board to enable high-frequency signal transmission. The fixing portion, which is on one side of the circuit board and apart from the coaxial connector, has a structure such that the horizontal tension of the circuit board is relaxed. In this mounting method, repetitive tension due to differences in linear expansion coefficient does not act on the soldered portion.

Electronic device with coaxial connectors for high-frequency circuit board

A semiconductor element module includes a package, a semiconductor element arranged on the package, and a plurality of leads provided on sides of the package so that an opening end of each the lead is oriented to the side of a package attaching plane, and serving to connect the semiconductor element to an external circuit; wherein a level differences is provided on the side of the package attaching plane of each of package sides so that a space is formed from each the plurality of leads.

Semiconductor element module and semiconductor device which prevents

An optical semiconductor device module comprising a light emitting element, an optical fiber, a light receiving element and an optical filter. The optical semiconductor module further includes a light absorbing-reflecting section for absorbing some of the stray beams which cannot pass through the optical filter, and reflecting some of such stray beams in a direction opposite to an optical axis of the beams. The light absorbing-reflecting section is present in a module casing such that it faces, on the optical axis, the light receiving element via the optical filter.

Optical semiconductor device module

An optical package includes a housing composed of two sections, a first section and a second section connectable to the first section. A laser holder is connected to the first section of the housing and adapted to hold a laser assembly. A fiber holder is connected to the second section of the housing and includes a ferrule by which an optical fiber is held. A rod lens is mounted within the housing to focus optical emission from the laser assembly on the optical fiber. The laser assembly includes a semiconductor element. Radial alignment of the semiconductor element and the laser holder is performed before the laser holder is secured to the first section of the housing. Axial alignment of the rod lens and the semiconductor element takes place while the laser holder is being fit in the first section of the housing. The second section of the housing is then moved in a radial direction relative to the optical axis of the semiconductor element and is, then, laser welded to the first section of the housing.

Method of fabricating an optical package

An optical semiconductor module which is connected to an optical fiber to introduce light from an optical semiconductor element into the optical fiber. The module comprises a holder which holds the semiconductor element, a housing which has a rod lens positioned therein and to which the holder is connected by fitting engagement made between one end of the housing and one end of the holder such that the optical axis of the semiconductor element and the optical axis of the rod lens coincide with each other, and a receptacle to which the optical fiber is connected, the receptacle being connected to the other end of the housing adjustably within a plane which perpendicularly intersects the optical axis of the optical fiber such that light from the semiconductor element that passes through the rod lens enters the optical fiber.

Optical semiconductor module

An optical semiconductor module comprises an optical semiconductor assembly having a light transmitting aperture, a housing having a joint surface at its one end to be joined to the optical semiconductor assembly, an outer male screw portion and a first hole for receiving an optical fiber supporter at its other end, a lens held in a second hole formed in the housing so as to be in communicatively alignment with the light transmitting aperture and the first hole, wherein a slitted sleeve is placed in a hole communicated with the first hole and a dummy ferrule with an axially extendly central bore for passing light is placed between the first hole and the lens so that one end portion of the dummy ferrule is inserted in the slitted sleeve so as to be in contact with the optical fiber supporter when it is fitted.

Growing community of inventors

Saitama, Japan

Akinobu Suzuki