The Green Cross Corporation

Akimasa Ohmizu

Takao Ohmura

Satoshi Funakoshi

Kazumasa Yokoyama

Tadakazu Suyama

Yahiro Uemura

Kazuo Takechi

Hirofumi Arimura

Akinori Sumi

Wataru Ohtani

Yutaka Hirao

Hiroshi Morise

Hajime Fukuyama

Yoshitaka Sakanishi

Katsuhiro Uriyu

Takuji Hanamura

Terufumi Fujiwara

Liquid preparation of antithrombin-III and stabilizing method therefor

A process for the purification of HBsAg is disclosed, which comprises adsorbing specifically on a carrier, in the presence of an inorganic salt in an amount of 5 to 25 W/V %, an HBsAg obtained by gene engineering.

Process for the purification of HBsAg

A lyophylized cold insoluble globulin preparation can be prepared in stable condition and in short time by lyophylizing an aqueous solution of a cold insoluble globulin in the presence of albumin and a neutral amino acid, a monosaccharide, a disaccharide or a sugar alcohol. The preparation dissolves in water without occurrence of turbidity and is usable for injection.

Method of lyophilizing cold insoluble globulin

A process for producing a hepatitis B infection preventing vaccine containing hepatitis B surface antigen as a main component thereof which comprises removing human plasma components possibly causing adverse effects and components capable of causing hepatitis B infection by incorporating steps of fractionation using ammonium sulfate, adsorption on a colloidal silicate and fractionation using polyethylene glycol into the purification stage after heat treatment and further carrying out a treatment for infectivity inactivation without causing any antigenicity impairment.

Process for producing a hepatitis B infection preventing vaccine

Growing community of inventors

Hirakata, Japan

Akimasa Ohmizu