Other

Daiichi Pharmaceutical Co., Ltd.

Drug Delivery System Institute, Ltd.

Akiko Togo

Masahiro Ikeda

Kazuhiro Inoue

Hiroshi Susaki

Hiroshi Kuga

Eiji Kumazawa

A drug complex characterized in that a residue of a drug compound such as antineoplastic agents and a carboxy(C)alkyldextran polyalcohol obtained by treating a dextran under conditions that enable substantially complete polyalcoholization are bound to each other by means of a spacer comprising an amino acid or a spacer comprising peptide-bonded 2 to 8 amino acids. Said complex is characterized in that it has excellent selectivity to tumorous sites so as to exhibit high antineoplastic activity and also achieves reduced appearance of toxicity.

Drug complex

A drug complex characterized in that a residue of a drug compound such as antineoplastic agents and a carboxy(C )alkyldextran polyalcohol obtained by treating a dextran under conditions that enable substantially complete polyalcoholization are bound to each other by means of a spacer comprising an amino acid or a spacer comprising peptide-bonded 2 to 8 amino acids. Said complex is characterized-in that it has excellent selectivity to tumorous sites so as to exhibit high antineoplastic activity and also achieves reduced appearance of toxicity.

Drug complexes

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Tokyo, Japan

Akiko Togo