Mitsubishi Tanabe Pharma Corporation

Akiko Tarao

Seigo Ishibuchi

Kazuhiro Maeda

Hidemasa Hikawa

Kaoru Tashiro

Jun-ichi Endoh

Jun-Ichi Endoh

Kunitomo Adachi

Maiko Hamada

Kenji Morokuma

Kunio Saruta

Tetsuji Matsudaira

Naoto Fujie

Maki Seki

Atsushi Kawata

Yukio Aoyama

Shingo Ogata

Takashi Honjo

Nobuatsu Matoba

Provided is a novel low-molecular-weight compound that suppresses production of induction type MMPs, particularly MMP-9, rather than production of hemostatic type MMP-2. The present invention relates to a compound represented by the following formula (I): wherein each symbol is as described in the DESCRIPTION. The compound has a selective MMP-9 production suppressive action, and is useful as a drug for the prophylaxis and/or treatment of autoimmune diseases such as rheumatoid arthritis and the like, inflammatory bowel diseases (ulcerative colitis, Crohn's disease) or osteoarthritis.

Imide derivatives and use thereof as medicine

Provided are a novel low-molecular-weight compound that suppresses production of induction type MMPs, particularly MMP-9, rather than production of hemostatic type MMP-2, as well as a prophylactic/therapeutic drug for autoimmune diseases or osteoarthritis. An amide derivative represented by the following formula (I) wherein each symbol is as defined in the specification, or a pharmacologically acceptable salt thereof.

Amide derivative and use thereof as medicine

Provided are a novel low-molecular-weight compound that suppresses production of induction type MMPs, particularly MMP-9, rather than production of hemostatic type MMP-2, as well as a prophylactic/therapeutic drug for autoimmune diseases or osteoarthritis. An amide derivative represented by the following formula (I) wherein each symbol is as defined in the specification, a pharmacologically acceptable salt thereof, or a hydrate or solvate thereof.

Oxazolidinone amide aromatic compounds for supressing MMP-9 production

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Osaka, Japan

Akiko Tarao