Ricoh Company, Ltd.

Dai Nippon Printing Co., Ltd.

Honda Giken Kogyo Kabushiki Kaisha

Riken Corporation

The University of Tokyo

Other

Plus Corporation

Nippon Leakless Kogyo Kabushiki Kaisha

Agc Inc.

Agc Chemicals Europe, Limited

Akiko Tanaka

Mitsuru Kitamura

Minoru Matsuo

Yuichi Jibiki

Yutaka Narita

Taisuke Tokuwaki

Hideki Komatsu

Makoto Nakamura

Shigeyuki Yokoyama

Toshio Yamagiwa

Takeshi Kuroe

Tadayuki Oshima

Hiroki Furubayashi

Hideo Namiki

Takenori Yamamoto

Tetsuo Nagano

Hirofumi Nakano

Akira Tanaka

Teruo Miyata

Kohei Miyazono

Hiroshi Itoh

Shinya Higuchi

Satoshi Iijima

Hayato Horie

Hirotatsu Kojima

Mikako Shirouzu

Takanori Kigawa

Masanao Abe

Hideki Akiyama

Takayoshi Okabe

Yoshitaka Yanagibashi

Hirofumi Yamamoto

Shigeki Kobayashi

Atsushi Tsukamoto

Ken Fujiwara

Tadayuki Ohshima

Keiko Tsuganezawa

Namtip Chumpolkulwong

Teruki Honma

Yasuko Koda

Hitomi Yuki

Yoshinobu Hashizume

Noriyuki Deguchi

Natsuko Matsuda

Sari Hiraoka

Atsushi Kanai

Katsuhiko Sekimata

Kentaro Yamashita

Hirokazu Kubota

Chie Takemoto

Hiroo Koyama

Tomonori Taguri

Tomohiro Sato

Nae Saito

Stamp for protecting personal information

The present invention relates to novel and excellent small-molecule-compounds that specifically antagonize BMP signal pathways, and these compounds can be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus can be used to treat diseases or pathological symptoms related to BMP signal pathway including inflammation, cardiovascular diseases, hematopoietic diseases, cancer, osteodystrophia, or the like, particularly, fibrodysplasia ossificans progressiva, and the present invention relates to provision of a pharmaceutical and pharmacological agent used for specifically antagonizing the BMP signal pathways and acting on the BMP signal pathways in the prevention and treatment or experimental application since the compounds can be beneficial for regulating cell differentiation and/or cell proliferation.

BMP-signal-inhibiting compound

An anticancer agent comprising a compound represented by the formula (I) [Rrepresents hydrogen atom, hydroxyl group, a Calkoxy group and the like; Rand Rrepresents hydrogen atom, a halogen atom, a Calkyl group and the like; Rrepresents hydrogen atom, a Calkyl group, a Calkylsulfonyl group and the like; Rrepresents hydrogen atom or a substituent;represents a single bond or a double bond; Rand Rrepresents hydrogen atom, a Calkyl group and the like; Rrepresents hydrogen atom, a Calkyl group and the like; A represents &#x2014;O&#x2014;, &#x2014;S&#x2014;, or &#x2014;CH&#x2014;; D represents &#x2014;C&#x2550; or &#x2014;N&#x2550;; X represents methylene group, &#x2014;O&#x2014;, or &#x2014;CO&#x2014;; Q represents &#x2014;N&#x2550; or &#x2014;C(R)&#x2550;; and Y represents a heterocyclic group or amino group], which shows a superior inhibitory activity against pim-1 kinase. 

Anticancer agent

The invention relates to a hologram that enables two or more different images to be simultaneously reconstructed even in a state where the hologram is fixed in terms of relative position with respect to an eye, and a holographic viewing device that incorporates it. The hologramis fabricated by applying Fourier transform to a plurality of input image to obtain a plurality of corresponding Fourier transform images--and arraying the Fourier transform images--on the same plane according to a given two-dimensional array principle into a computer-generated hologram. When a plurality of point light sourcestolocated behind the hologramare viewed through the hologram, a plurality of images are simultaneously and parallel reconstructed () in correspondence to the array positions of the plurality of Fourier transform images.

Hologram and holgraphic viewing device incorporating it

A conductive member () includes a conductive supporting body (), an electric resistance adjusting layer (), which is formed onto the conductive supporting body () and is disposed to face a photoconductor (), and a pair of space holding members () disposed in both ends of the electric resistance adjusting layer (), so as to have contact with the photoconductor () to maintain a predetermined gap (G) between the electric resistance adjusting layer () and the photoconductor, and each of the space holding members () includes a cylinder portion () attached to the outer circumference surface () of the electric resistance adjusting layer and an end plate () provided in one end portion of the cylinder portion and disposed to have contact with the end surface () of the electric resistance adjusting layer.

Conductive member, process cartridge having the same, and image forming apparatus having the process cartridge

A method for fabricating a computer generated hologram or holographic stereogram can reconstruct a three-dimensional object having visualized cross-sectional surfaces, wherein three-dimensional object composed only of surface data is processed to have visualized cross-sectional surfaces on a given cross section thereof by adding surface data to cross-sectional surfaces. The method includes obtaining volume data of a three-dimensional object, obtaining a number of two-dimensional cross-sectional image data of the three-dimensional object, producing three-dimensional object image data composed only of surface data of the three-dimensional object from the two-dimensional cross-sectional data obtained above, cutting the three-dimensional object surface data along predetermined cross section, defining the shape by adding surface data representing cross-sectional surfaces on the cut cross section, defining the arrangement of the defined three-dimensional object, a hologram plan and a reference beam to compute interference fringes on the hologram plane, and recording the interference fringes on a recording medium.

Fabrication method for a computer-generated hologram in which a three-dimensional object having visualized cross-sectional surfaces is recorded, and computer-generated hologram in which a three-dimensional object having visualized cross-sectional surfaces is recorded

A conductive member including a conductive supporting body (), an electric resistance adjusting layer () formed on the conductive supporting body (), and space holding members () provided on opposite ends of the electric resistance adjusting layer (), at least one engaging projection () being provided on one of the electric resistance adjusting layer () and each of the space holding members (), and an engaging opening () in which the engaging projection is inserted being provided in the other of the electric resistance adjusting layer () and each of the space holding members ().

Conductive member and process cartridge having it and image forming apparatus having the process cartridge

Hologram and holographic viewing device incorporating it

It is intended to provide a process for producing an extract for cell-free protein synthesis whereby the productivity of a protein and the production efficiency can be improved. Cells are cultured under suppressed growth conditions. In the stationary phase of the culture, the cells are collected and then disrupted. The above-described cells are preferably bacterial cells, in particular,cells. In the suppressed growth conditions as described above, the culture temperature is preferably from 20 to 32&#xb0; C., more preferably 26&#xb0; C. or higher and lower than 30&#xb0; C.

Process for producing extract for cell-free protein synthesis and cell extract produced thereby

The invention provides a diffractive optical element that can be used as a light beam splitter device, an optical low-pass filter or the like having a two-dimensionally multi-valued fine periodic structure. The surface of a transparent substrate for the diffractive optical element is divided into fine rectangular areas of identical shape which line up in two orthogonal directions while a plurality of rows line up with ends in alignment in any one of the directions. With respect to standard wavelength light incident vertically on the surface of the transparent substrate, an l-th, and a (l+1)-th rectangular area in an l-th row, where l is an odd number, gives a phase 2p&#x3c0;, and a phase {(4q+1)&#x3c0;/2+&#x3b4;&#x3c0;/2}, respectively, and an l-th, and a (l+1)-th rectangular area in a (l+1)-th row gives a phase {(4r+3)&#x3c0;/2+3&#x3b4;&#x3c0;/2}, and a phase {(4s+2)&#x3c0;/2+&#x3b4;&#x3c0;}, respectively. However, &#x2212;0.25&#x2266;&#x3b4;&#x2266;0.25, and p, q, r, and s is an integer.

Diffractive optical element and optical low-pass filter utilizing the same

A method for fabricating a computer-generated hologram or a holographic stereogram can reconstruct a three-dimensional object having visualized cross-sectional surfaces, wherein the three-dimensional object composed only of surface data is processed to have visualized cross-sectional surfaces on a given cross section thereof by adding surface data to cross-sectional surfaces. The method includes obtaining a number of two-dimensional cross-sectional image data of a three-dimensional object, producing three-dimensional object image data composed only of surface data of the three-dimensional object from the two-dimensional cross-sectional image data obtained above, cutting the three-dimensional object surface data along a predetermined cross section, defining the shape by adding surface data representing cross-sectional surfaces on the cut cross section to the same, defining the arrangement of the defined three-dimensional object, a hologram plane, and a reference beam to compute interference fringes on the hologram plane, and recording the interference fringes on a recording medium.

Fabrication method for a computer-generated hologram or a holographic stereogram in which a three-dimensional object having visualized cross-sectional surfaces is recorded and computer-generated hologram/holographic

The viscosity of a puncture-preventing sealant () is set in a range of 25 to 35 dPa&#xb7;s, and a thixotropy index is set in a range of 6.5 to 11.0, the sealant () being filled in a sealant chamber () defined to extend along an outer periphery of an air chamber () in a tire (T). When the tire (T) is being rotated by traveling of a vehicle, the viscosity of the sealant () is reduced by a stirring action provided by a vibration or a centrifugal force of the sealant (), whereby the sealant () can be diffused uniformly in the sealant chamber (). When the vehicle has been stopped and the stirring action has been extinguished, the viscosity of the sealant () is increased, whereby the sealant () is maintained in a state in which it has been diffused uniformly in the sealant chamber () without flowing downwards in the sealant chamber () by gravitation. Therefore, even when the vehicle is travelling at a high speed, the generation of a vibration and a noise can be prevented. In this manner, the puncture-preventing sealant is provided, which has such a nature that the sealant is easy to flow due to a low viscosity during traveling of a vehicle, and the sealant is difficult to flow due to a high viscosity when the sealant is left to stand.

Sealant for prevention of blowout, tubeless tire, and tire tube

A conductive member includes a conductive supporting body, an electric resistance adjusting layer disposed on a surface of the conductive supporting body, and a space adjusting mechanism including a material different from the electric resistance adjusting layer, which is disposed on the surface of the conductive supporting body and is firmly fixed to an end portion of the electric resistance adjusting layer, wherein the space adjusting mechanism is provided to form a space between an outer surface of the electric resistance adjusting layer and an outer surface of a photoconductor.

Conductive member and process cartridge and image forming apparatus using the same

A film is made of an insulating matrix resin and an electroconductive material, in which the electroconductive material is dispersed in the insulating matrix resin in such a manner that a surface resistivity of A [&#x3a9;] of the film and a volume resistivity of B [&#x3a9;&#xb7;cm] of the film in the direction of a thickness thereof normal to the surface of the film satisfy a relationship of: A&#x3e;B, and when the film has a thickness of T [cm], the electroconductive material is dispersed in the insulating matrix resin in such a manner that the surface resistivity of A [&#x3a9;] of the film and the volume resistivity of B [&#x3a9;&#xb7;cm] of the film satisfy a relationship of: A[&#x3a9;]&#xd7;T[cm]&#x3e;B[&#x3a9;&#xb7;cm]. This film can be prepared by a centrifugal molding method.

Film for use in intermediate image transfer member and method of producing endless-belt-shaped film

Growing community of inventors

Tokyo, Japan

Akiko Tanaka