Toyama Chemical Co., Ltd.

Akiko Takagi

Isamu Saikawa

Nobuo Terashima

Yasuyuki Suzuki

Noboru Takagawa

Mikio Kawabata

Tetsuo Fukushima

Mariko Hayashi

Takako Wakamiya

Disclosed is a protein kinase C enhancer characterized by containing a benzothiophene alkyl ether derivative represented by the general formula below or a salt thereof.  (In the formula, Rand Rmay be the same or different and represent one or more groups selected from a hydrogen atom, a halogen atom, an alkyl group, an aryl group, an aralkyl group, an alkoxy group, an aryloxy group, an alkenyl group, an amino group, a heterocyclic group, an optionally protected amino group, a hydroxyl group, a carboxyl group, an oxo group and the like; Rrepresents an alkylamino group, an amino group, a hydroxyl group or the like; and m and n may be the same or different and represent an integer of 1-6.) This protein kinase C enhancer is useful for treatment or prevention of various diseases associated with protein kinase C.

Protein kinase C activity enhancer containing alkyl ether derivative or salt thereof

The process for producing bischoline-disulfonate derivatives of Formula (I) ##STR1## useful for enhancing the digestive function comprising reacting, in the presence of an organic solvent, a trimethylammonium salt derivative of Formula (II) ##STR2## wherein R.sup.1 and R.sup.2 are individually lower alkyl and X is a group removable by a disulfonic acid of Formula (III)

Novel process for producing bischoline-disulfonate derivatives

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Toyama, Japan

Akiko Takagi