Yamanouchi Pharmaceutical Company Ltd.

Akiko Orita

Makoto Takeuchi

Atsushi Ichikawa

Souichirou Kawazoe

Hiroyuki Hisamichi

Kazuhito Tanabe

Takayuki Suzuki

Kenichi Onda

Akira Toyoshima

Ryo Naito

Eiichi Nakai

A nitrogen-containing six-membered heterocyclic compound having substituents &mdash;X&mdash;A&mdash;R , &mdash;N(R )-(Ph substituted by R ), and &mdash;CONH , a salt thereof, a prodrug thereof, and a Syk inhibitor containing the same as an active ingredient. (In the formula, A: a (substituted) lower alkylene, a (substituted) arylene, or the like; X: NR , CONR , NR CO, O, or S; R , R : H, a lower alkyl, &mdash;CO-lower alkyl, or &mdash;SO -lower alkyl; R : H, a (substituted) lower alkyl, &mdash;O-lower alkyl, &mdash;S-lower alkyl, &mdash;O-aryl, nitro, cyano, or the like; R : &mdash;CO H, &mdash;CO -lower alkyl, -lower alkylene-CO H, &mdash;NH , -alkylene-NH or the like.

Heterocyclecarboxamide derivative

Pyrimidine-5-carboxamide derivatives

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Ibaraki, Japan

Akiko Orita