Ajinomoto Co., Ltd.

Akiko Oonuki

Toshihiko Yoshimura

Naoyuki Fukuchi

Hideyuki Tanaka

Katsumi Maezono

Yayoi Kawato

Nozomu Ishida

Hideki Matsumoto

Masayuki Sugiki

Manabu Kitazawa

Munetaka Tokumasu

Mitsuo Takahashi

Yoichiro Shima

Haruko Hirashima

Yasuko Nogi

The present invention provides PPAR (peroxisome proliferator-activated receptor) activity regulators, which can be widely used for improving insulin resistance and preventing/treating various diseases such as diabetes, metabolic syndromes, hyperlipemia, high-blood pressure, vascular disorders, inflammation, hepatitis, fatty liver, liver fibrosis, NASH (non-alcoholic steatohepatitis) and obesity.

PPAR activity regulators

The present invention provides a novel compound having a kininogenase-inhibitory action and its pharmaceutical use. The compounds are represented by the formulas (A), (B), (C), (E) and (H): wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof.

Aniline derivatives

The object of the present invention is to provide PPAR (peroxisome proliferator-activated receptor) activity regulators, which can be widely used for improving insulin resistance and preventing/treating various diseases such as diabetes, metabolic syndromes, hyperlipemia, high-blood pressure, vascular disorders, inflammation, hepatitis, fatty liver, liver fibrosis, NASH (non-alcoholic steatohepatitis) and obesity. The present invention provides PPAR activity regulators which comprise an acylamide compound having the specific structure, prodrugs thereof, or pharmaceutically acceptable salts thereof.

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Kawasaki, Japan

Akiko Oonuki