Olympus Optical Company, Ltd.

Toppan Printing Co., Ltd.

The University of Tokyo

Konica-minolta Holdings, Inc.

Tokyo University of Pharmacy & Life Sciences

Kokusan Chemical Co., Ltd.

Konica Minolta, Inc.

Akihiro Taguchi

Akio Nakada

Hitoshi Karasawa

Masaaki Hayashi

Kenji Yoshino

Tetsumaru Kubota

Takashi Fukaya

Keisuke Saito

Susumu Takahashi

Toyoharu Hanzawa

Syuichi Takayama

Shinji Hatta

Nobuaki Akui

Akihiko Mochida

Toshihiko Hashiguchi

Atsushi Kidawara

Iwao Kanamori

Tatsuo Nagasaki

Shinji Yamashita

Katsuyuki Saito

Kenji Harano

Tadao Hagino

Makoto Tsunakawa

Wataru Ohno

Tsuyoshi Tsukagoshi

Shinichi Imade

Hitoshi Mizuno

Takeshi Yamazaki

Akinobu Uchikubo

Hiroyoshi Fujimori

Shuichi Kimura

Akira Shiga

Masao Uehara

Yoshinao Oaki

Kuniaki Kami

Mamoru Kaneko

Junichi Onishi

Shiro Bito

Akira Murata

Minoru Tsuruta

Seiji Kuramoto

Masahito Goto

Tsutomu Hirai

Toshiki Terayama

Shingo Kato

Hiroyuki Kusunoki

Akito Mukaizawa

Koji Taguchi

Yasukazu Tatsumi

Yoshio Hayashi

Kenya Inomata

Kuniyasu Obara

Kyou Imagawa

Hideki Koyanagi

Yasuhiro Ueda

Sakae Takehana

Takashi Tsukaya

Hideyuki Adachi

Shuichi Takayama

Naomi Sekino

Koji Yasunaga

Toshihiko Suzuta

Naoki Uchiyama

Tatsuya Kubota

Yoshiaki Take

Takashi Takemura

Yutaka Ohshima

Hiroshi Takahashi

Akio Nakata

Ryoichi Matsuda

Kouji Tanikawa

Kazuhiko Oozeki

Takashi Muramatsu

Daisaku Negoro

Yoshihiro Kosaka

Tetsushi Aoki

Satoshi Honma

Masanori Kaneda

Yoshito Ichikawa

Minoru Maekawara

Masaya Yoshihara

Yukiko Nagaoka

Shingo Tsubotani

Ryouichi Konou

Masataka Shiozuka

Satoshi Takemoto

Kyo Imagawa

Fumika Yakushiji

Kentaro Fukumoto

Yuri Yamazaki

Nobuya Yamamoto

Hitoshi Mizno

The present invention provides a means capable of selectively introducing a disulfide bond with respect to two free thiol groups located in a molecule of an organic compound such as a peptide, or the like, in a short time by a simple treatment and also by a chemically stable method. A nitrogen-containing compound represented by Chemical Formula 1 below or a salt thereof:  The symbols shown in Chemical Formula 1 are the same as defined in the specification.

Selective disulfidation reagent using nitrogen-containing compound and method for producing disulfide-containing compound

[Problem] Provision of a novel compound having read-through activity and a drug for the treatment of nonsense mutation-type disease containing this compound. [Solution] A compound represented by the following general formula (1): and a pharmaceutical composition containing this compound.

Compound having read-through activity

An inkjet recording apparatus includes: exchangeable first and second ink cartridges; a recording head which jets ink to a recording medium; an intermediate tank which receives the ink from the ink cartridge and supplies the ink to the recording head; a detecting sensor which detects whether ink residual quantity of an ink cartridge is not more than predetermined quantity based on ink quantity in the intermediate tank; a switching section which, if the ink residual quantity is not more than the predetermined quantity, switches the ink cartridge for supplying the ink to the intermediate tank; a first detector which detects the reset of the first ink cartridge; a second detector which detects the reset of the second ink cartridge; and a controller which, if the first ink cartridge is reset, controls the switching section to switch the second ink cartridge to the first ink cartridge, for supplying the ink.

Inkjet cartridge detection and switching apparatus

Using an endoscope system, a surgeon A holds an endoscope with a TV camera (hereinafter, an endoscope) and a therapeutic appliance such as forceps and carries out a surgical procedure while viewing a first monitor. A surgeon B holds a therapeutic appliance such as forceps and carries out the surgical procedure while viewing a second monitor. A video signal sent from the TV camera of the endoscope is fed to and processed by an image processing apparatus, and displayed on each of the first and second monitors. The image processing apparatus transfers the video signal sent from the endoscope to each of an image inverting circuit and a selector switch. The image inverting circuit inverts an image (laterally (to produce a mirror image), vertically, or vertically and laterally (180&deg;)), and supplies a processed video signal to the selector switch. The selector switch selects a video signal to be supplied to each of the first and second monitors, which are display units, in response to a control signal sent from a selector. The contents of processing to be performed by the image inverting circuit and the video signal to be selected by the selector are designated using setting switches on an operation panel.

Image processing apparatus for performing turn or mirror inversion on an input video signal and outputting different images simultaneously

A stereoscopic endoscope including an objective lens system for forming an image of an object which objective lens system is arranged at the front end of an inserting section and has a single optical axis; an image transmission device coaxially arranged with the objective lens system and adapted to transmit the image formed by the objective lens system; a pupil dividing device for dividing the image transmitted through the objective lens system and the image transmission device so as to obtain left and right images of the object; an image sensing device for picking up the left and right images obtained by the pupil dividing device; a first support structure containing at least the objective lens system; and a second support structure containing at least the pupil dividing device and the image sensing device, wherein the first and second support structures are rotatable relative to each other around an axis extending along the longitudinal dimension of the endoscope.

Stereoscopic endoscope

An apparatus for holding a medical instrument, such as an endoscope, in place without exerting an undue force on an insertion hole in an abdominal cavity of a subject even when the arm of a scope-holding section is unlocked, includes a four-link parallelogram mechanism. The four-link parallelogram mechanism includes a support arm for supporting a treating tool, an arm section parallel to the support arm and upper and lower arm sections connected to the upper and lower end sides of the support arm and arm section in a parallel relation. A support mechanism supports the arm sections of the four-link parallelogram mechanism to allow the arm sections to be moved in left/right and up/down directions, while being rotated, so that a straight line connecting an intersecting point P of a center line of the treating instrument inserted into an insertion hole in an abdominal wall of a subject and the center of the insertion hole to spherical bearings of the arm is set parallel to the upper and lower arm sections.

Apparatus for holding a medical instrument in place

A medical system control apparatus including a plurality of pieces of medical equipment having respective identification numbers thereof individually, and having display portions on which setting conditions or operating conditions are displayed and operating portions for modifying the setting conditions or the operating conditions which are displayed on the display portions, a centralized controller for controlling the plurality of pieces of medical equipment, a centralized display device connected to the controller and provided with a display portion which displays the display contents of the plurality of pieces of medical equipment, a centralized operation device connected to the controller for controlling the setting conditions or the operating conditions which are displayed on the display portions of the plurality of pieces of medical equipment, and a communication device for enabling the plurality of pieces of medical equipment, the centralized display device and the centralized operation device and the controller to communicate with each other in a bidirectional manner.

System control apparatus, medical system control apparatus and

A stereoscopic endoscope including an objective lens system for forming an image of an object which objective lens system is arranged at the front end of an inserting section and has a single optical axis; an image transmission device coaxially arranged with the objective lens system and adapted to transmit the image formed by the objective lens system; a pupil dividing device for dividing the image transmitted through the objective lens system and the image transmission device so as to obtain left and right images of the object; an image sensing device for picking up the left and right images obtained by the pupil dividing device; a first support structure containing-at least the objective lens system; and a second support structure containing at least the pupil dividing device and the image sensing device, wherein the first and second support structures are rotatable relative to each other around an axis extending along the longitudinal dimension of the endoscope.

A three-dimensional vision endoscopic apparatus according to the present invention comprises a pair of optical systems for transmitting an image of a subject as two subject images having a parallax between them, a pair of imaging devices for picking up subject images transmitted by the optical systems, at least one visual field mask, a display unit for displaying the two subject images alternately or concurrently, an adjusting mechanism for adjusting the position of one or both of the imaging devices so that the display images will become consistent on the screen of the display unit, and an adjusting mechanism for adjusting the relative position of the visual field mask.

Three-dimensional vision endoscope with position adjustment means for

A surgical device for stapling and fastening body tissues, which comprises a staple-applying section containing a plurality of staples, a staple pusher incorporated in the staple-applying section, for applying the staples, an anvil section for deforming the staples, thereby to staple the body tissues together, an operation section for operating the staple pusher and the anvil section, an observation window located near the anvil section, and an ocular section for displaying images supplied from the observation window.

Surgical device for stapling and fastening body tissues

A surgical device for stapling and fastening body tissues, comprises an insertion section extending from an operation section for insertion into a body cavity, stapling member connected to a distal end of the insertion section, for treating body tissues with a high-frequency current within a body cavity. The stapling member includes an anvil and a cartridge between which the tissues are sandwiched, and a cutter. Staples are applied to the anvil from the cartridge for stapling the tissues and the cutter cuts the tissue while it applies a high-frequency current thereto.

Surgical device for stapling and/or fastening body tissues

A container is provided for recovering a used treating liquid, and is composed of an outer box and a flexible inner bag, the inner bag being held within the outer box and having a partition wall by means of which the interior thereof is divided into a treating-liquid storage chamber and a used-liquid storage chamber, the storage chambers each having an access port by way of which each is connected to an outer associated apparatus.

Container for recovering a used treating liquid

A closure of a liquid container, such as plastic bottles or chemical bottles, has a cap made of a resilient material and provided with a central opening-and-closing protrusion erected. By fitting a stopper of a relatively hard material onto the cap and provided with an engagement part onto the cap, the contents of the container can be poured and kept at its pouring or dispensing condition after the protrusion is rotated and engaged or hooked with the engagement part by a thumb and finger of the operator or user of the bottle. It is easy to release the hooked or engaged condition of the protrusion of the cap to the lever of the stopper, permitting the contents to be stopped from dispensing instantly.

Liquid container closure lockable in the open position

A medical resecting device is disclosed in which, a living organism tissue is resected with ultrasonic vibrations while the corresponding body cavity is observed with an optical observation pipe. The resecting device includes an ultrasonic vibrator for generating ultrasonic vibrations, a horn connected to the vibrator, a probe connected to the front portion of the horn to transmit the ultrasonic vibrations generated by the vibrator, the probe being provided with a rod-like shaft and a distal end portion with a resecting blade, a power source unit for supplying a drive voltage to the vibrator, and an optical observation pipe having a guide hole in which the shaft of the probe is inserted.

Resecting device for living organism tissue utilizing ultrasonic

A medical treatment device for resecting, e.g., a prostate or breaking a bladder stone, which includes a vibrator for generating ultrasonic vibrations, a horn connected to the vibrator, a casing for accommodating the vibrator and the horn, a probe connected to the front portion of the horn to transmit ultrasonic vibrations generated by the vibrator, and a power source unit for supplying a drive voltage to the vibrator, the power source unit having an oscillator for producing a wave having a frequency for vibrating the probe and a frequency switching circuit for selecting an oscillating frequency at which the distal end of the probe serves as a loop of vibration or a frequency at which the distal end of the probe serves as a node of vibration.

Medical treatment device utilizing ultrasonic wave

Growing community of inventors

Tokyo, Japan

Akihiro Taguchi