Fujirebio Kabushiki Kaisha

Unitika Ltd.

Fujirebio Inc.

Nec Corporation

Seikagaku Corporation

Akihiro Sekine

Tetsuaki Yamaura

Yoshikazu Isowa

Hajime Matsumoto

Yasuo Sekine

Akihiko Hosoda

Noriaki Kashiwaba

Hiroshi Nakajima

Nobuhiko Hirakawa

Masashi Nishikawa

Kazuo Okada

Masahiro Shibata

Nobuo Kobayashi

Tsuneo Koji

Teruo Kutsuma

Masafumi Kitakaze

Masaharu Dozen

Tetsuaki Yamura

Nobuhiro Hirakawa

Hisako Harada

Masatsugu Hori

Takenobu Kamada

Yoshinori Kikuta

Shinkichi Tezuka

Naoko Tanabe

Naoko Koji

In a remote conference system based on a client server model, each of conference terminals comprises a terminal packet memory for storing a voice data of the conference terminal. When a synthesized voice data is multicasted to the conference terminals, each of the conference terminals searches own voice data included in the synthesized voice data from the terminal packet memory. An echo canceler in each of the conference terminals cancels own voice data from the synthesized voice data, thereby performing an echo canceling processing.

Remote conference system using multicast transmission for performing echo cancellation

A cyclic amide derivative of formula (I): ##STR1## wherein R.sup.1 represents a substituted alkyl group, a substituted alkenyl group, a substituted amino group, a substituted alkoxyl group, a substituted alkylthio group, a substituted carbamoyl group, a substituted sulfonamide group or a substituted amide group; the ring A represents a saturated cyclic alkyl group with 5 to 7 carbon atoms or a hetero-atom-containing saturated heterocyclic group with 3 to 6 carbon atoms; R.sup.2 represents a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aromatic hydrocarbon group or a substituted or unsubstituted heterocyclic group; R.sup.3 represents a hydrogen atom, a group represented by the general formula R.sup.4 O-- or a group represented by the general formula R.sup.5 (R.sup.6)N-- wherein R.sup.4 represents hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aromatic hydrocarbon group or a substituted or unsubstituted heterocyclic group; R.sup.5 and R.sup.6 may be the same or different and each represents a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aromatic hydrocarbon group or a substituted or unsubstituted heterocyclic group. The cyclic amide derivative of formula (I) have a strong and selective inhibitory action of a cathepsin K and a clinical efficacy when administered orally.

Cyclic amide derivatives

An agent for curing ischemic myocardial disease which contains an effective amount of diadenosine 5',5''-p.sup.1,p.sup.4 -tetraphosphate (Ap4A) of formula (I): ##STR1## or a pharmaceutically-acceptable salt thereof.

Agent for curing ischemic myocardial disease

A deliberated hypotensive agent is composed of diadenosine 5', 5''-p.sup.1,p.sup.4 -tetraphosphate with formula (I) or a salt thereof for which administration is medically permissible in an effective amount: ##STR1##

Ap.sub.4 A as a hypotensive agent

The compounds of the formulas (VI) and (VII) are useful intermediates in producing pyridyloxy derivatives of the formula (I), such as, for instance, N-{4-[4-(piperidinomethyl)pyridyl-2-oxy]-2-butenyl}-2-(furfurylt hio)acetamide, which are useful as anti-peptic ulcer agents. The compounds of formula (VI) have the formula ##STR1## wherein A represents a formyl group, a protected formyl group, a hydroxymethyl group or a protected hydroxymethyl group. The compounds of formula (VIII) have the formula ##STR2## wherein G represents a formyl group, a protected formyl group, a hydroxymethyl group, a hydroxymethyl group in which the hydroxyl group is protected, or a halogenomethyl group, Y represents --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--, and n is 0, 1 or 2.

Intermediates for pyridyloxy compounds having utility as anti-peptic

A compound represented by the following formula or a salt thereof ##STR1## wherein each of R.sub.1 and R.sub.2 represents a lower alkyl group, or R.sub.1 and R.sub.2, together with the nitrogen atom to which they are bonded, may form a substituted or unsubstituted, saturated or partially unsaturated 4- to 8-membered heterocyclic group which may contain a hetero atom selected from N, O and S, Y represents a group of the formula --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH--, and n is 0, 1 or 2. This compound is useful as anti-peptic ulcer agent.

4-aminomethyl-pyridyl-2-oxy derivatives having anti-ulcer activity

Alkylamide derivatives having the formula, These compounds have a strong antiulcer action depend on histamine H.sub.2 -receptor antagonistic action and a cytoprotective action upon gastric mucous membrance.

Alkylamide derivatives with H.sub.2 -receptor antagonistic and

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Tokyo, Japan

Akihiro Sekine