Nissan Chemical Corporation

Peptidream Inc.

Nissan Chemical Industries Limited

Akihiro Nagaya

Michiharu Handa

Hiroyuki Kousaka

Keiichi Masuya

Hirohide Kitsuyama

Hironobu Yoshino

Ikumasa Hidaka

Douglas Robert Cary

Naohiko Yasuda

Kazuya Wakui

Yukio Asaka

Hisayuki Takeuchi

Haruaki Kurasaki

Madoka Yoshino

Tomonori Taguri

Yoshitaka Nemoto

Yutaka Kobayashi

Yuji Mimori

Ayumu Matsuda

The invention provides a method for producing a peptide by (1) removing the N-terminal protective group of an amino acid or peptide compound of formula (I): wherein Y represents a residue of an N-protected amino acid or an N-protected peptide, and each of R, R, and Rindependently represents an aliphatic hydrocarbon group which may have a substituent or an aromatic hydrocarbon group which may have a substituent, wherein the total number of carbon atoms in the RRRSi group is 18 to 80, and the RRRSiCHCHgroup is bonded to the C-terminus of the amino acid or peptide residue in Y; and (2) causing condensation of an N-protected amino acid or an N-protected peptide and the N-terminus of the C-protected amino acid or C-protected peptide obtained in the step (1).

Method for producing peptide compound

The invention provides a method for producing a triorganosilane compound which includes (1) a step of reacting a diorganosilane compound represented by the formula (I): with a triflating reagent to obtain a monotriflate compound represented by the formula (III): and(2) a step of reacting the monotriflate compound obtained in the step (1) with a metal reagent represented by RLi or RMgX to obtain a triorganosilane compound represented by the formula (II): wherein R, Rand Rare as defined herein.

Method for producing triorganosilane compound

The present invention is to provide a method for producing a peptide containing an N-alkylamino acid, which comprises the following Steps (1) to (3). Step (1): a step of mixing an N-terminal protected amino acid or an N-terminal protected peptide with a carboxylic acid halide or a halogenated alkyl formate; Step (2): a step of mixing an amino acid or a peptide in which the N-terminal and the C-terminal are not protected with a trialkylsilylating agent; and Step (3): a step of mixing the product obtained in Step (1) with the product obtained in Step (2).

The invention provides a method for producing a peptide which comprises the following steps (1) and (2): (1) a step of condensing a C-protected amino acid or a C-protected peptide to a C-terminal of an N-protected amino acid or an N-protected peptide represented by the formula (I): wherein Y represents an amino acid in which a C-terminal is unprotected or a peptide in which a C-terminal is unprotected, R, Rand Reach independently represent an aliphatic hydrocarbon group which may have a substituent(s), a total number of the carbon atoms in the RRRSi group is 10 or more, and the RRRSiOC(O) group is bonded to the N-terminal in Y, and (2) a step of removing the protective group at the C-terminal of the peptide obtained in step (1).

A method for producing a high-purity nitrogen-containing heterocyclic compound includes: a process (a) and a process (b): (a) a process of mixing a mixture containing a compound and as an impurity compound with a solvent and a metal salt, and (b) a process of obtaining a mixture in a solution state in which the content of the compound has decreased compared to that in the mixture in the process (a) by filtering a mixed solution obtained in the process (a), or a process of obtaining a mixture in which the content of the compound has decreased compared to that in the mixture in the process (a) by further evaporating the solvent or crystallizing following the filtering; (where Rand Rare each independently a hydrogen atom, a Calkyl group, etc., Ris a hydrogen atom, a Calkyl group, etc., X is a hydrogen atom, etc.).

Production method of high-purity nitrogen-containing heterocyclic compound

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Funabashi, Japan

Akihiro Nagaya