Takara Shuzo Co., Inc.

Osaka University

Horiba, Ltd.

Takara Bio Inc.

Irica Instruments, Inc.

Akihiro Kondo

Ikunoshin Kato

Nobuto Koyama

Naoyuki Taniguchi

Takatoshi Nakagawa

Hiroaki Sagawa

Eiji Kobayashi

Katsushige Ikai

Tatsuji Enoki

Akira Obayashi

Eiji Nishiyama

Hiromu Ohnogi

Mutsumi Sano

Hiromi Ohkawa

Hua-Kang Wu

Eiji Miyoshi

Yuan C Lee

Takeshi Mori

Tsuyoshi Miyamura

Suzu Deguchi

Kaoru Takegawa

Kojiro Miki

Shojiro Iwahara

Jian Qiang Fan

Hideki Iijima

Shinichiro Shinzaki

Masahiko Tsujii

Norio Hayashi

Motoko Ueda

Sumihiro Hase

Yoshiyuki Kato

Hisao Tsuruta

Wenzhe Li

Yumi Hosokawa

The instant invention provides a method for the differential diagnosis of inflammatory bowel disease which comprises, determining the relative ratio of G0 oligosaccharide represented by formula (I): to G2 oligosaccharide represented by formula (II): wherein G represents galactose, M represents mannose, GN represents N-acetylglucosamine and F represents fucose in serum IgG oligosaccharide fraction obtained from a patient with inflammatory bowel disease or a patient with suspicion of inflammatory bowel disease, anddiscriminating inflammatory bowel disease based on the obtained ratio.

Method for determination of inflammatory bowel disease

Disclosed is a means for reducing the expression amount of a FUT8 gene, reducing the expression amount of a FUT8 protein, and/or reducing the expression amount of a product produced by the action of FUT8.

Composition for suppressing the expression of fucosyltransferase

Product of heat treatment of uronic acid, food, drink, or drug including the product

To provide a process for producing a carbohydrate or a glycoconjugate without forming any hydrolytic product of the remodeled sugar chain. A process for producing a carbohydrate or a glycoconjugate by a remodeling reaction in the presence of a glycosidase which performs the remodeling reaction in an aqueous medium containing a water-soluble ketone and/or dioxane. Examples of the glycosidase include endoglycosidases such as Endo-A. Examples of the ketone include acetone.

Process for producing carbohydrate or glycoconjugate

A more exact, reliable, and simple method for determining the structure of a sugar chain, a kit to be used for this method, and novel oligosaccharides useful for the method as standard sugar chains are provided. The method for determining the structure of an N-acetyllactosamine type of sugar chain is characterized by determining the site of linkage and the mode of linkage of sugar residues at the non-reducing terminal side of a .beta.-N-acetylglucosamine residue linked to an .alpha.-mannose residue in M3 core by means of detecting the presence of the .beta.-N-acetylglucosamine residue after enzymatic or chemical treatment of the sugar chain. The kit for determining the structure of an N-acetyllactosamine type of sugar chain is characterized by containing at least one of the oligosaccharides represented by the chemical formula 1. The oligosaccharide is represented by the chemical formula 4.

Method for determining sugar chain structure

Pretreatment apparatus and process for analysis of sugar, the apparatus including a mechanical work hand which moves a vial containing a sample to various stations where reagents are added to the vial and where other pretreatment processes are performed on the sample. The pretreatment apparatus automatically controls the movement of the vial from one station to another and the various processes performed at each station, the processes including removal and storage of the vial's cap, addition of reagents into the vial, centrifugation and heating of the sample, and evaporation of excess reagents.

Pretreatment apparatus for analysis of sugar

A reagent reaction apparatus for automatically performing a reaction by introducing various kinds of reagents to a sample solution. The reagent reaction apparatus includes a number of sample vials within a containing section and a plunger valve with fluid introducing port and a fluid discharge port located on top of the containing section. A mechanism sequentially injects into the sample vial a predetermined amount of reagents into a sample vial containing a measured amount of sample solutions. The sample vial is held in a rotary cone in order to apply centrifugal force. Then, the sample solution and reagents are subjected top a temperature adjusting bath which is preselected for the required reaction temperature. A mechanism transports the final product in the sample vial to a discharge station.

Reagent reactor apparatus

A method for the fluorescent labelling of a sugar or a sugar chain by labelling the reducing end of the sugar or sugar chain with a fluorescent substance, wherein the improvement comprises first forming a Schiff base by reacting the surgar or sugar chain with the fluorescent substance in the presence of an acid which is substantially free from water, and second, reducing said Schiff base.

Method for the fluorescent labelling of sugars

Growing community of inventors

Muko, Japan

Akihiro Kondo