Japan Science and Technology Agency

The University of Tokyo

Teijin Limited

Akihiro Kishimura

Kazunori Kataoka

Yasutaka Anraku

Akinori Goto

Kanjiro Miyata

Makoto Oba

Tomoya Suma

Sayan Chuanoi

Nobuhiro Nishiyama

Mitsuru Sakai

Yutaka Miura

Horacio Cabral

Tsuneo Saga

Ichio Aoki

Aya Koide

Stephanie Lee

QiuMing Yu

Peng Mi

Daisuke Kokuryo

Qiuming Yu

Provided is a monodisperse agglomerate of a substance-containing vesicle filled with a substance at a concentration higher than conventionally possible. A mixed solution, in which a target substance is included in an aqueous medium, is mixed with a monodisperse agglomerate of a crosslinked vesicle comprising a prescribed polymer which includes a first polymer, i.e. a block copolymer having uncharged hydrophilic segments and first charged segments, and a second polymer having second charged segments carrying a charge opposite to that of the first charged segments, and in which the first polymer and/or the second polymer are/is crosslinked. As a result, the crosslinked vesicle is made to contain the target substance.

Substance-containing vesicle, and production method therefor

Provided is a method for easily and efficiently producing encapsulated substance vesicles wherein a substance is encapsulated in the cavity of vesicles obtained by polymer self-assembly. Empty vesicles that have membranes comprising a first polymer that is a block copolymer with uncharged hydrophilic segments and a first kind of charged segments and a second polymer with a second kind of charged segments that carry a charge that is the opposite of said first kind of charged segments as well as spaces that are enclosed by said membranes are mixed in an aqueous medium with the substance that is to be encapsulated in the spaces.

Substance-encapsulating vesicle and process for producing the same

The present invention provides a safe polymer nanoparticle composite with few side effects, and an MRI contrast agent incorporating said polymer nanoparticle composite. The polymer nanoparticle composite is capable of specifically accumulating on a tumor tissue to selectively extract the tissue, exhibiting high contrast even when used in small amounts, and enabling imaging over prolonged periods of time. This polymer nanoparticle composite is characterized by containing a block copolymer that includes a non-charged hydrophilic polymer chain segment and an anionic polymer chain segment, and MnCaP.

Polymer nanoparticle composite and composition for MRI imaging including same

The purpose of the present invention is to provide an electrostatically bonded vesicle which bears disulfide bonds or thiol groups. The present invention relates to a vesicle having a membrane which is formed from both a first polymer of (a) or (b) and a second polymer of (c) or (d) (with the proviso that a combination of (b) and (d) is excepted) and in which the cationic segment and anionic segment of the polymers are partially crosslinked. First polymer: (a) a block copolymer (I) having both an electrically non-charged hydrophilic segment and a cationic segment, (b) an amino acid polymer (I) having a cationic segment. Second polymer: (c) a block copolymer (II) having both an electrically non-charged hydrophilic segment and an anionic segment, (d) an amino acid polymer (II) having an anionic segment.

Electrostatically bonded vesicle

Growing community of inventors

Tokyo, Japan

Akihiro Kishimura