Sankyo Company, Limited

Akihiro Kawara

Keisuke Suzuki

Tomio Kimura

Shigeru Ushiyama

Akira Nakao

Masaaki Miyamoto

Yasuo Noguchi

Compounds of formula (I) and (II):[wherein R is hydrogen, halogen or alkyl; Ris alkyl, amino or substituted amino; Ris optionally substituted phenyl; Ris hydrogen, halogen or optionally substituted alkyl; Ris hydrogen, optionally substituted alkyl, cycloalkyl, aryl, or aralkyl] have valuable analgesic, anti-inflammatory, anti-pyretic and anti-allergic activities and have the ability to inhibit the production of leukotrienes and to inhibit bone resorption. They are relatively free from the side effects which generally result from the administration of compounds having these kinds of activities.

1,2-Diphenylpyrrole derivatives, their preparation and their therapeutic uses

Compounds of formula (I) and (II): ##STR1## �wherein R is hydrogen, halogen or alkyl; R.sup.1 is alkyl, amino or substituted amino; R.sup.2 is optionally substituted phenyl; R.sup.3 is hydrogen, halogen or optionally substituted alkyl; R.sup.4 is hydrogen, optionally substituted alkyl, cycloalkyl, aryl, or aralkyl! have valuable analgesic, anti-inflammatory, anti-pyretic and anti-allergic activities and have the ability to inhibit the production of leukotrienes and to inhibit bone resorption. They are relatively free from the side effects which generally result from the administration of compounds having these kinds of activities.

1,2-diphenylpyrrole derivatives, their preparation and their therapeutic

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Yokohama, Japan

Akihiro Kawara