Fujisawa Pharmaceutical Company, Ltd.

Astellas Pharma Gmbh

Akihiro Kasai

Kazumi Ohtomo

Seiji Sawai

Hajime Konno

Kazumi Otomo

Jiro Fujisaki

A stabilized pharmaceutical composition in lyophilized form comprising: a cyclic polypeptide compound represented by the general formula (I): wherein Ris a hydrogen atom or an acyl group and Rand Rare, the same or different, a hydrogen atom or a hydroxyl group, or a salt thereof and the stabilizer.

Stabilized pharmaceutical composition in lyophilized form

The present invention provides a pipecolic acid derivative-containing liposome preparation having has an excellent rapid action capable of coping with an emergent situation such as cerebral infarction. A liposome preparation characterized by comprising, as an active ingredient, a pipecolic acid derivative of the ingredient described in the present specification or a pharmaceutically acceptable salt thereof entrapped into liposomes, wherein lecithin is mainly used as the liposome-forming lipid, said liposome preparation containing no cholesterol as a stabilizer.

Liposome preparations

An object of the present invention is to provide a method for producing a liposome preparation having excellent rapid action and excellent redispersion into aqueous medium. The present invention provides a method for producing a liposome preparation by vacuum drying wherein liposome condensed solution, which is obtained by removing solvent from liposome solution, is subjected to vacuum drying without freezing while bubbling the condensed solution or after the condensed solution is bubbled.

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Ikoma, Japan

Akihiro Kasai