Shiseido Company, Limited

Fujisawa Pharmaceutical Company, Ltd.

Akihiro Ishino

Kiyoshi Miyazawa

Koji Kobayashi

Hirotada Fukunishi

Takehisa Hata

Masahiro Tajima

Kenichi Umishio

Yoshiharu Tsuji

Toshiyasu Honbo

Chika Hamada

Jotaro Nakanishi

Daigo Mizumoto

Seishiro Fujii

Takanari Tsuda

Keiichi Uchikawa

Tomoko Yokoyama

A hair growth inhibitor contains, as an active ingredient, at least one herb selected from the group consisting of phellodendron bark, houttuynia, rice bran, mulberry tree bark, Japanese coptis, thyme, peach seed, nettle, calendula, wild rose and balm mint or the extract thereof and various skin external application compositions such as cosmetic compositions to be used on the outer skin is prepared by mixing these active ingredients with other aqueous phase ingredients and oil phase ingredients according to conventional-methods.

Hair growth inhibitors and composition containing same

A 1,2-di-substituted piperidine derivative or a salt thereof expressed by the following Formula (I): ##STR1## wherein one of A and B is a hydrocarbon group of C.sub.1-30 expressed by R.sup.1 and the other is --(CH.sub.2)n-NR.sup.2 R.sup.3 ; Y is --CO--, --CONR.sup.5 -- or --COO--; Z is --O--, --OCO--, --OCONR.sup.6 -- or --NR.sup.6 --; R.sup.2 and R.sup.3 individually represent a hydrogen a lower alkyl, a phenyl or a benzyl group, or together represent a heterocycle having 3-7 members; --NR.sup.5 --(CH.sub.2)n-NR.sup.2 R.sup.3 and --NR.sup.6 --(CH.sub.2)n-NR.sup.2 R.sup.3 of --(Y).sub.1 --A and --Z--B may be the following Group W: ##STR2## wherein ring E is a heterocycle of 6 or 7 members including two nitrogen atoms and R.sup.2 is a hydrogen, a lower alkyl, a phenyl or a benzyl group; R.sup.4 is a hydrogen, a halogen, a lower alkyl, a lower acyl, a nitro, a cyano, a lower alkoxycarbonyl, a carbamoyl, a lower alkylcarbamoyl, a lower alkylamino, a lower acylamino, a lower alkoxy or a lower acyloxy group; each of R.sup.5 and R.sup.6 is a hydrogen, a lower alkyl, a lower acyl, a lower alkylcarbamoyl group, or a part of said ring E; l is 0 or 1; m is an integer of 2-5; and n is an integer of 0-5. The 1,2-di-substituted piperidine derivative or the salt thereof has excellent hair growth and regrowth promoting effects, which are useful for care, improvement or prevention of hair loss in mammals and, in particular, in human.

1,2-DI-substituted piperidine derivative, hair growth promoter and

A hair revitalizing agent including a compound represented by the formula shown below or a pharmaceutically acceptable salt thereof: ##STR1## (wherein R.sup.1 to R.sup.10, R.sup.14 to R.sup.23, X, Y, and n are the same as defined in the present specification).

Hair revitalizing agent

Hair revitalizing tonic composition

A hair revitalizing tonic having an excellent hair loss prevention and hair revitalizing effect comprising (1) an amine oxide or (2) an amine oxide and an anionic surfactant formulated therein.

Growing community of inventors

Yokohama, Japan

Akihiro Ishino