Shionogi Company Limited

Akihiro Hori

Akira Kato

Kazuo Ueda

Naotake Kobayashi

Naohiro Itoh

Gaku Sakaguchi

Hidekazu Haraguchi

Ken Yasui

Shinji Suzuki

Akira Yukimasa

Yasuhiko Kanda

Yuji Koriyama

Moriyasu Masui

Yuuji Kooriyama

Terukazu Kato

Tatsuhiko Ueno

Shuji Yonezawa

Chiaki Fujikoshi

Sae Matsumoto

The present invention provides, for example, a compound mentioned below as a medicament for treating or preventing the diseases induced by production, secretion or deposition of amyloid-&#x3b2; proteins. A compound of the formula (I): wherein R, R, R, R, R, R, ring A and the dashed lines are defined in the specification,its pharmaceutically acceptable salt or a solvate thereof.

Oxazine derivatives

The following compound is provided as an agent for treating a disease induced by production, secretion and/or deposition of amyloid &#x3b2; protein, for example, 

Sulfur-containing heterocyclic derivative having beta secretase inhibitory activity

A composition having BACE 1 inhibitory activity containing a compound represented by the formula (I): 

Aminodihydrothiazine derivatives

A pharmaceutical composition for treating Alzheimer's disease containing a compound represented by the general formula (I): 

Pharmaceutical composition for treating alzheimer's disease

A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): 

A pharmaceutical composition for treating Alzheimer's disease containing a compound represented by the general formula (I); wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group;

Pharmaceutical composition for treating Alzheimer's disease

The following compound is provided as an agent for treating a disease induced by production, secretion and/or deposition of amyloid &#x3b2; protein, for example, a compound represented by the formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group,Ris optionally substituted lower alkyl or the like,Rand Rare each independently hydrogen, optionally substituted lower alkyl or the like,Rand Rare each independently hydrogen, halogen, hydroxy, optionally substituted lower alkyl or the like,or a pharmaceutically acceptable salt thereof, or a solvate thereof.

A composition having BACE 1 inhibitory activity containing a compound represented by the formula (I): wherein ring A is an optionally substituted heterocyclic group;E is lower alkylene;X is S;Ris a hydrogen atom or lower alkyl;R, R, R, R, Rand Ris each independently a hydrogen atom, halogen, or hydroxy etc.;n and m are each independently an integer of 0 to 3;n+m is an integer of 0 to 3;Ris a hydrogen atom or substituted lower alkyl;or its pharmaceutically acceptable salt thereof.

A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group;

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Osaka, Japan

Akihiro Hori