Teikoku Seiyaku Co., Ltd.

Terumo Kabushiki Kaisha

Akihiro Hasui

Mitsutoshi Yaegashi

Hirokazu Takahashi

Kenichi Hattori

Yukiko Inamoto

Mitsuhiro Kawada

Makoto Takahashi

Ken-ichi Hattori

Shinji Tanaka

Takamitsu Miyagi

Hiroyuki Kubo

Atsuhiko Shiraishi

Ken-Ichi Hattori

The present invention verifies a method of reducing skin irritation (particularly, cumulative skin irritation) caused by transdermal administration of a local anesthetic using iontophoresis, and provides an electrode pad for relief from a puncture pain which is safe not only at single administration but also at repeated administrations. The electrode pad comprises a base sheet; an electrode placed on the base sheet; an adhesive sheet placed on the base sheet and having an opening, within which the electrode being exposed; and a medicament reservoir containing a local anesthetic and placed in the opening of the adhesive sheet while being in contact with the electrode. An inner peripheral surface of the opening of the adhesive sheet and an outer peripheral surface of the medicament reservoir are prevented from coming into contact with human skin while contacting with each other, and thereby skin irritation is reduced.

Electrode pad used for iontophoresis treatment

An iontophoresis patch is equipped with a donor gel and a reference gel which are disposed to contact an external conductor, for example, the skin of a patient and thereby output current from a current-carrying device to the external conductor. The iontophoresis patch includes: a donor portion having the donor gel containing a medical agent to be penetrated into the external conductor; a reference portion having a reference gel, mounted with the current-carrying device on the surface on the side opposite to the reference gel, and disposed on the external conductor apart from the donor portion; and an electrode film for supplying current from the current-carrying device to the donor gel and the reference gel.

Iontophoresis patch

The present invention provides an electrode device used in iontophoresis treatment, in which an electrode layer used for introduction of medication can be contacted to a medication reservoir layer with a simple manner, and in which the medication reservoir layer can be reliably held when the medication is introduced into a skin. A main-electrode layerand a sub-electrode layerare secured on a substratewhile both the layers are being insulated from each other. The main-electrode layeris intended for introduction of the medication, and the sub-electrode layeris provided to hold the medication reservoir layeron the substrate. The medication reservoir layeris located on the substrate, so as to be in contact with the main-electrode layerand the sub-electrode layer. The medication reservoir layeris a gel containing halogen compound, and the sub-electrode layercomprises a metal having a lower ionization tendency than hydrogen. The medication reservoir layerand the sub-electrode layerare bonded to each other by applying an electric current to both layers. In this way, the medication reservoir layercan be firmly held on the substrate, while being kept in contact with the main-electrode layer

Electrode device used in iontophoresis treatment

External preparations for treatment of painful skin wound having an analgesic activity which comprises acetylsalicylic acid or its pharmacologically acceptable salt as an active ingredient.

External preparation for treating painful skin wound

It is an object of the present inventions to produce a pharmaceutical composition for the iontophoresis wherein a drug stability is excellent, and it is easy to blend and fill up when manufactured and it is possible to manufacture at low cost. A pharmaceutical composition for an iontophoresis according to the present invention, is characterized in that the composition contains a nonionic synthetic polymer, betamethasone sodium phosphate and solvent. Furthermore, in a preferred embodiment of a pharmaceutical composition for an iontophoresis according to the present invention, the composition is characterized in that the nonionic synthetic polymer is polyvinyl alcohol (PVA). Furthermore, in a preferred embodiment of a pharmaceutical composition for an iontophoresis according to the present invention, the composition is characterized in that the mixing amount of the polyvinyl alcohol (PVA) is 0.5 to 30.0 percent by weight.

Pharmaceutical composition of an iontophoresis

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Higashikagawa, Japan

Akihiro Hasui