The Doshisha

National Center for Geriatrics and Gerontology

Akihiko Takashima

Hachiro Sugimoto

Yoshikazu Inoue

Rie Tokizane

Tetsuo Ota

Yasuo Ihara

Tomohiro Miyasaka

Yuki Shinzaki

Yohei Oe

Yoshiyuki Soeda

A tau aggregation inhibitor can sufficiently inhibit a tau protein from aggregating in cells. The inhibitor includes a 4-substituted catechol structure compound, having, at position 4 of its catechol ring, an electron-donating substituent R other than a hydrocarbon group, or a salt thereof. The 4-substituted catechol structure compound is preferably 4-aminocatechol or 1,2,4-benzenetriol. Examples of tauopathies to which this inhibitor is applicable include AD, Down's syndrome, frontotemporal dementia, cotricobasal degeneration (CBD) and progressive supranuclear palsy (PSP).

Tau aggregation inhibitor

Growing community of inventors

Saitama, Japan

Akihiko Takashima