Mitsui Chemicals, Inc.

Japan Tobacco Inc.

Akihiko Takahashi

Ichisaburo Nakamura

Masaaki Ozawa

Hiroshi Ueno

Seiichi Masuko

Sunao Maeda

Hironobu Nagamori

Koichi Suzawa

Tomoya Miura

Dai Motoda

Yuzo Ono

Yosuke Ogoshi

Kazuhito Ueyama

Kazuyuki Sugimoto

Toshihiko Iwayama

Katsuhito Kohketsu

Yoshihiro Umeda

The present invention provides a pyrazole compound of the following general Formula [Ib] having SGLT1 inhibitory activity, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the same, and its pharmaceutical use: wherein each symbol is the same as defined in the description.

Pyrazole compound and pharmaceutical use thereof

A process for polymerizing a vinyl chloride monomer wherein the vinyl chloride monomer is subjected to homopolymerization or (co)polymerization with a monomer copolymerizable with the vinyl chloride monomer in an aqueous solvent, comprising applying in advance a coating liquid containing a cocondensation product obtained by reacting either a phenothiazine derivative and an aldehyde or a phenothiazine derivative, a naphthol derivative and an aldehyde to give an initial condensation product and then reacting the initial product with a polyphenol, to an inner wall of a polymerization tank and parts of an apparatus in contact with the monomers during the polymerization process. The process makes it possible to apply the cocondensation product as an aqueous solution to, e.g., an inner wall of a polymerization tank; to quite effectively prevent polymer adhesion in, e.g., a polymerization tank, without affecting a polymerization rate or physical properties of the product; and thus to eliminate the need for removing adhered polymer after every polymerization process and to realize closed polymerization in which a manhole should not be opened for every polymerization process.

Polymerization of vinyl chloride

A process is provided for the polymerization of vinyl chloride in a closed mode. According to the process, oxygen is caused to exist in a polymerizer, which is coated with an anti-fouling agent, during an operation in which the polymerization is repeated. The process according to this invention has made it possible to fully exhibit effects of the anti-fouling. This has in turn made it possible to achieve polymerization of vinyl chloride in the closed mode, leading to an improvement in productivity.

Polymerization process of vinyl chloride in the presence of oxygen

A method for the homopolymerization or copolymerization of vinyl chloride, wherein the inner wall of the polymerizer and the like are prevented from being fouled with the resulting polymer by applying a coating fluid containing the oxidative polymerization product of a specific phenolic monomer to the surface of the inner wall of the polymerizer and the like, as well as an anti-fouling agent used for this purpose. The method of this invention can very effectively prevent the polymerizer and the like from being fouled with the resulting polymer without affecting the polymerization rate and various properties of the product. Consequently, the necessity of performing the operation for removal of the deposited polymer after completion of each polymerization cycle is eliminated, thus making it possible to achieve closed polymerization requiring no manhole opening after each polymerization cycle which is becoming increasingly popular in recent years.

Method for preventing the inner wall surfaces of the polymerization

Growing community of inventors

Osaka, Japan

Akihiko Takahashi