Tanabe Seiyaku Company, Limited

Akihiko Sumi

Ichiro Chibata

Osamu Ohtsuki

Nozomu Izutsu

Hiroshi Ito

Novel di-L-cysteine L-malate of the formula:

Di-L-cysteine L-malate and process for the production thereof

A novel crystalline salt of a basic L-amino acid with L-malic acid, particularly a neutral crystalline salt consisting of 2 moles of L-lysine, L-ornithine or L-arginine with 1 mole of L-malic acid, which have no bitter taste and can be administered by oral route as a nutritive supplement or as a medicine, and further contain no chloride ion and hence are useful for preparing an infusion solution with no undesirable side effect due to chloride ion.

Crystalline salt of basic L-amino acid with L-malic acid and process for

An aqueous solution of L-malic acid and potassium ion is prepared having a pH of no more than 6.8. The aqueous solution is cooled to initiate crystallization of a potassium salt of L-malic acid, and the aqueous mixture obtained is allowed to stand at a pH of 5.3 to 6.8 until it substantially reaches liquid-solid equilibrium. The resultant crystals of monopotassium L-malate monohydrate are collected therefrom. The monopotassium L-malate monohydrate thus obtained may be dried to give the corresponding anhydrate. Monopotassium L-malate and its monohydrate are stable, non-hygroscopic crystals.

Growing community of inventors

Ashiya, Japan

Akihiko Sumi